Pharmacokinetics of Voriconazole in Peritoneal Fluid of Critically Ill Patients
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DOI: 10.1128/aac.01721-22
Abstract: Data on the distribution of voriconazole (VRC) in the human peritoneal cavity are sparse. This prospective study aimed to describe the pharmacokinetics of intravenous VRC in the peritoneal fluid of critically ill patients. ABSTRACT Data… read more here.
Keywords: ill patients; vrc; critically ill; fluid critically ... See more keywords
Population pharmacokinetics of voriconazole and initial dosage optimization in patients with talaromycosis
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DOI: 10.3389/fphar.2022.982981
Abstract: The high variability and unpredictability of the plasma concentration of voriconazole (VRC) pose a major challenge for clinical administration. The aim of this study was to develop a population pharmacokinetics (PPK) model of VRC and… read more here.
Keywords: vrc; initial dosage; patients talaromycosis; dosage ... See more keywords
Towards the Elucidation of the Pharmacokinetics of Voriconazole: A Quantitative Characterization of Its Metabolism
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DOI: 10.3390/pharmaceutics14030477
Abstract: The small-molecule drug voriconazole (VRC) shows a complex and not yet fully understood metabolism. Consequently, its in vivo pharmacokinetics are challenging to predict, leading to therapy failures or adverse events. Thus, a quantitative in vitro… read more here.
Keywords: metabolism; vrc; inhibition; characterization metabolism ... See more keywords