Pharmacokinetics of Voriconazole in Peritoneal Fluid of Critically Ill Patients
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DOI: 10.1128/aac.01721-22
Abstract: Data on the distribution of voriconazole (VRC) in the human peritoneal cavity are sparse. This prospective study aimed to describe the pharmacokinetics of intravenous VRC in the peritoneal fluid of critically ill patients. ABSTRACT Data… read more here.
Keywords: ill patients; vrc; critically ill; fluid critically ... See more keywords
Clinical application of voriconazole in pediatric patients: a systematic review
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DOI: 10.1186/s13052-024-01684-z
Abstract: The purpose of this study was to review the literature on the clinical use of voriconazole (VRC) in pediatric patients. MEDLINE, Embase, PubMed, Web of Science, and Cochrane Library were searched from January 1, 2000,… read more here.
Keywords: vrc pediatric; vrc; systematic review; pediatric patients ... See more keywords
A Systematic Review of Population Pharmacokinetics, Safety, and Factors Influencing Trough Concentrations of Voriconazole in Asian Patients with Liver Dysfunction
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DOI: 10.2147/dddt.s553073
Abstract: Objective This study systematically reviews recent research on voriconazole (VRC) use in Asian patients with liver dysfunction to provide a scientific basis for individualized therapy. Methods A comprehensive literature search was conducted in EMBASE, PubMed,… read more here.
Keywords: vrc; patients liver; asian patients; liver dysfunction ... See more keywords
In vitro interactions of proton pump inhibitors and azoles against pathogenic fungi
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DOI: 10.3389/fcimb.2024.1296151
Abstract: Introduction Azole resistance has been increasingly reported and become an issue for clinical managements of invasive mycoses. New strategy with combination therapy arises as a valuable and promising alternative option. The aim of the present… read more here.
Keywords: vrc; proton pump; pathogenic fungi; itc pos ... See more keywords
Population pharmacokinetics of voriconazole and initial dosage optimization in patients with talaromycosis
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DOI: 10.3389/fphar.2022.982981
Abstract: The high variability and unpredictability of the plasma concentration of voriconazole (VRC) pose a major challenge for clinical administration. The aim of this study was to develop a population pharmacokinetics (PPK) model of VRC and… read more here.
Keywords: vrc; initial dosage; patients talaromycosis; dosage ... See more keywords
Personalizing voriconazole dosing in Chinese hematological patients: CYP2C19 phenotype and albumin-bilirubin grade as key predictors of trough concentrations
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1667461
Abstract: Purpose This retrospective, single-center study aimed to evaluate the genetic and non-genetic factors influencing voriconazole (VRC) trough concentration (C trough), efficacy and safety in hematological patients. Methods Medical records of inpatients were reviewed retrospectively. Univariate… read more here.
Keywords: hematological patients; albumin bilirubin; vrc; cyp2c19 phenotype ... See more keywords
Towards the Elucidation of the Pharmacokinetics of Voriconazole: A Quantitative Characterization of Its Metabolism
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DOI: 10.3390/pharmaceutics14030477
Abstract: The small-molecule drug voriconazole (VRC) shows a complex and not yet fully understood metabolism. Consequently, its in vivo pharmacokinetics are challenging to predict, leading to therapy failures or adverse events. Thus, a quantitative in vitro… read more here.
Keywords: metabolism; vrc; inhibition; characterization metabolism ... See more keywords
Voriconazole-Loaded Nanohydrogels Towards Optimized Antifungal Therapy for Cystic Fibrosis Patients
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DOI: 10.3390/pharmaceutics17060725
Abstract: Background/Objectives: Filamentous fungi, in particular the species Aspergillus, Scedosporium, and Exophiala, frequently colonize the lungs of cystic fibrosis (CF) patients. Chronic colonization is linked to hypersensitivity reactions and persistent infections leading to a significant long-term… read more here.
Keywords: vrc; loaded nanohydrogels; fibrosis patients; cystic fibrosis ... See more keywords
Formulation Studies on Microemulsion-Based Polymer Gels Loaded with Voriconazole for the Treatment of Skin Mycoses
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DOI: 10.3390/pharmaceutics17091218
Abstract: Background: Skin mycoses affect approximately 10% of the global population, and the range of effective topical antifungal agents remains limited. Voriconazole (VRC) is a broad-spectrum triazole with proven efficacy against drug-resistant fungal infections. This study… read more here.
Keywords: vrc; menthol; skin mycoses; skin ... See more keywords