Priming VRC01-precursor B cells with non-envelope immunogens disfavors boosting with HIV-1 envelope
Sign Up to like & getrecommendations! Published in 2025 at "NPJ Vaccines"
DOI: 10.1038/s41541-025-01235-5
Abstract: VRC01-class antibodies are a genetically restricted class of antibodies capable of potently neutralizing diverse strains of HIV-1. Unmutated VRC01 precursors fail to recognize recombinant HIV-1 Envelope (Env) proteins, which necessitated the development of germline targeting… read more here.
Keywords: vrc01 class; envelope; class; vrc01 ... See more keywords
A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention
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DOI: 10.1080/19420862.2021.1946918
Abstract: ABSTRACT Passive transfer of broadly neutralizing antibodies is showing promise in the treatment and prevention of HIV-1. One class of antibodies, the VRC01 class, appears especially promising. To improve VRC01-class antibodies, we combined structure-based design… read more here.
Keywords: class antibodies; class; matrix; vrc01 class ... See more keywords
Short CDRL1 in intermediate VRC01-like mAbs is not sufficient to overcome key glycan barriers on HIV-1 Env
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DOI: 10.1128/jvi.00744-24
Abstract: ABSTRACT VRC01-class broadly neutralizing antibodies (bnAbs) have been isolated from people with HIV-1, but they have not yet been elicited by vaccination. They are extensively somatically mutated and sometimes accumulate CDRL1 deletions. Such indels may… read more here.
Keywords: cdrl1; broadly neutralizing; vrc01 class; neutralizing antibodies ... See more keywords