A novel VRK1 mutation associated with recessive distal hereditary motor neuropathy
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.701
Abstract: Vaccinia‐related kinase 1 (VRK1) mutations can cause motor phenotypes including axonal sensorimotor neuropathy, distal hereditary motor neuropathy (dHMN), spinal muscular atrophy, and amyotrophic lateral sclerosis. Here, we identify a novel homozygous VRK1 p.W375X mutation causing… read more here.
Keywords: distal hereditary; hereditary motor; motor; vrk1 ... See more keywords
Histone Lactylation‐Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells
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DOI: 10.1002/advs.202503897
Abstract: Glioblastoma (GBM) is the most malignant primary brain tumor in adults, with glioma stem cells (GSCs) as a subpopulation contributing to treatment resistance and recurrence. This study investigates the role of lactate and its regulatory… read more here.
Keywords: vrk1; stem; stemness proliferation; gscs ... See more keywords
The human VRK1 chromatin kinase in cancer biology.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.12.032
Abstract: VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is overexpressed in many types of tumors and associated with a poor prognosis. Chromatin VRK1 phosphorylates several transcription factors, including p53,… read more here.
Keywords: chromatin; biology; vrk1; cancer ... See more keywords
Lentinan suppresses the progression of neuroblastoma by inhibiting FOS-mediated transcription activation of VRK1 to stabilize p53 protein
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02315-0
Abstract: Neuroblastoma (NB) is a common malignant and solid pediatric tumor with unfavorable prognosis. Although studies have shown the anti-tumor efficacy of lentinan (LNT), molecular mechanism that contribute to the anti-tumor effect on NB remains unclear.… read more here.
Keywords: fos; vrk1; p53 protein; tumor ... See more keywords
Vrk1 partial Knockdown in Mice Results in Reduced Brain Weight and Mild Motor Dysfunction, and Indicates Neuronal VRK1 Target Pathways
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DOI: 10.1038/s41598-018-29215-x
Abstract: Mutations in Vaccinia-related kinase 1 (VRK1) have emerged as a cause of severe neuronal phenotypes in human, including brain developmental defects and degeneration of spinal motor neurons, leading to Spinal Muscular Atrophy (SMA) or early… read more here.
Keywords: vrk1gt3 gt3; motor; vrk1; mice ... See more keywords
Abstract 6950: VRK1 as a novel therapeutic target in small cell neuroendocrine carcinoma of the uterine cervix via mitochondrial dysfunction
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6950
Abstract: [Objective] Small cell neuroendocrine carcinoma of the uterine cervix (SCNEC) is a rare cancer with a poor prognosis, highlighting the pressing need for effective pharmacotherapies. Our previous proteomic analysis identified vaccinia-related kinase 1 (VRK1) as… read more here.
Keywords: vrk1; carcinoma; mitochondrial dysfunction; cell ... See more keywords
Overexpression of the VRK1 kinase, which is associated with breast cancer, induces a mesenchymal to epithelial transition in mammary epithelial cells
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DOI: 10.1371/journal.pone.0203397
Abstract: Vaccinia-related kinase 1 (VRK1) is a pro-proliferative nuclear kinase. Mice engrafted with VRK1-depleted MDA-MB-231 breast cancer cells have been shown to develop fewer distal metastases than controls, suggesting VRK1 might play a role in cell… read more here.
Keywords: overexpression; vrk1; vrk1 overexpression; breast cancer ... See more keywords