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   Articles with "vrk1" as a keyword



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A novel VRK1 mutation associated with recessive distal hereditary motor neuropathy

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recommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"

DOI: 10.1002/acn3.701

Abstract: Vaccinia‐related kinase 1 (VRK1) mutations can cause motor phenotypes including axonal sensorimotor neuropathy, distal hereditary motor neuropathy (dHMN), spinal muscular atrophy, and amyotrophic lateral sclerosis. Here, we identify a novel homozygous VRK1 p.W375X mutation causing… read more here.

Keywords: distal hereditary; hereditary motor; motor; vrk1 ... See more keywords
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The human VRK1 chromatin kinase in cancer biology.

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recommendations! Published in 2021 at "Cancer letters"

DOI: 10.1016/j.canlet.2020.12.032

Abstract: VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is overexpressed in many types of tumors and associated with a poor prognosis. Chromatin VRK1 phosphorylates several transcription factors, including p53,… read more here.

Keywords: chromatin; biology; vrk1; cancer ... See more keywords

Vrk1 partial Knockdown in Mice Results in Reduced Brain Weight and Mild Motor Dysfunction, and Indicates Neuronal VRK1 Target Pathways

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-29215-x

Abstract: Mutations in Vaccinia-related kinase 1 (VRK1) have emerged as a cause of severe neuronal phenotypes in human, including brain developmental defects and degeneration of spinal motor neurons, leading to Spinal Muscular Atrophy (SMA) or early… read more here.

Keywords: vrk1gt3 gt3; motor; vrk1; mice ... See more keywords

Overexpression of the VRK1 kinase, which is associated with breast cancer, induces a mesenchymal to epithelial transition in mammary epithelial cells

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recommendations! Published in 2018 at "PLoS ONE"

DOI: 10.1371/journal.pone.0203397

Abstract: Vaccinia-related kinase 1 (VRK1) is a pro-proliferative nuclear kinase. Mice engrafted with VRK1-depleted MDA-MB-231 breast cancer cells have been shown to develop fewer distal metastases than controls, suggesting VRK1 might play a role in cell… read more here.

Keywords: overexpression; vrk1; vrk1 overexpression; breast cancer ... See more keywords