VRK1 Is a Synthetic–Lethal Target in VRK2-Deficient Glioblastoma
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DOI: 10.1158/0008-5472.can-21-4443
Abstract: A paralog synthetic–lethal interaction between VRK1 and VRK2 sensitizes VRK2-methylated glioblastoma to perturbation of VRK1 kinase activity, supporting VRK1 as a drug discovery target in this disease. read more here.
Keywords: synthetic lethal; glioblastoma; lethal target; vrk1 synthetic ... See more keywords