Association of Retinoic Acid Receptor &bgr; Gene With Onset and Progression of Lichen Sclerosus–Associated Vulvar Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2018.1373
Abstract: Importance Molecular alterations in lichen sclerosus–associated vulvar squamous cell carcinoma (LS-VSCC) are largely unknown. Objective To determine whether the retinoic acid receptor &bgr; (RAR&bgr;) tumor-suppressor gene is involved in the onset and/or progression of LS-VSCC.… read more here.
Keywords: bgr; rar bgr; vscc; normal skin ... See more keywords
Somatic mutation profiling of vulvar cancer: Exploring therapeutic targets.
Sign Up to like & getrecommendations! Published in 2018 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2018.06.026
Abstract: BACKGROUND Vulvar squamous cell carcinoma (VSCC) constitutes over 90% of vulvar cancer. Its pathogenesis can follow two different pathways; high risk human papillomavirus (hrHPV)-dependent and HPV-independent. Due to the rarity of VSCC, molecular mechanisms underlying… read more here.
Keywords: hrhpv hrhpv; somatic mutation; vscc; hrhpv ... See more keywords
Potential targets for tumor-specific imaging of vulvar squamous cell carcinoma: A systematic review of candidate biomarkers.
Sign Up to like & getrecommendations! Published in 2020 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2019.12.030
Abstract: INTRODUCTION Vulvar squamous cell carcinoma (VSCC) is a rare malignancy with an increasing incidence, especially in young women. Surgical treatment of VSCC is associated with significant morbidity and high recurrence rates, which is related to… read more here.
Keywords: vscc; tumor specific; vulvar squamous; specific imaging ... See more keywords
CPC15 Vulval squamous cell carcinoma is an under-reported cancer associated with poor outcomes: a national cohort study of the incidence and survival in England
Sign Up to like & getrecommendations! Published in 2025 at "British Journal of Dermatology"
DOI: 10.1093/bjd/ljaf085.015
Abstract: Epidemiological data are limited for vulval squamous cell carcinoma (VSCC). This retrospective, national cohort study reports the incidence and survival of VSCC from 2013 to 2020 in England. Data were extracted from the National Disease… read more here.
Keywords: cancer; vscc; incidence survival; incidence ... See more keywords
Differentiated vulvar intraepithelial neoplasia long‐term follow up and prognostic factors: An analysis of a large historical cohort
Sign Up to like & getrecommendations! Published in 2024 at "Acta Obstetricia et Gynecologica Scandinavica"
DOI: 10.1111/aogs.14814
Abstract: Differentiated vulvar intraepithelial neoplasia (dVIN) is a high‐risk preinvasive vulvar lesion and precursor of human papillomavirus‐independent vulvar squamous cell carcinoma (VSCC). Due to its rarity, literature data on its malignant potential are scant. The aim… read more here.
Keywords: dvin; vscc; differentiated vulvar; intraepithelial neoplasia ... See more keywords
Human papillomavirus and p53 status define three types of vulvar squamous cell carcinomas with distinct clinical, pathological, and prognostic features.
Sign Up to like & getrecommendations! Published in 2023 at "Histopathology"
DOI: 10.1111/his.14925
Abstract: INTRODUCTION Based on their etiological relationship with human papillomavirus (HPV), the 2020 WHO classification has divided vulvar squamous cell carcinomas (VSCC) into two distinct types, HPV-associated and HPV-independent, and HPV-independent tumours have recently been divided… read more here.
Keywords: vscc; hpv independent; p53 status; p53 ... See more keywords
Molecular and immune characterization of squamous cell ovarian cancers for identification of therapeutic targets.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.5584
Abstract: 5584 Background: Squamous cell carcinoma (SCC) represents 10 mt/MB). PD-L1 IHC positivity was determined by a cut-off of >1% CPS (22c3, Agilent) and >2|5% (SP142, Spring Biosciences). HPV status determined by WES for HPV16 and… read more here.
Keywords: compared eoc; cell; vscc; ccoc ... See more keywords
Inflammatory Proteins HMGA2 and PRTN3 as Drivers of Vulvar Squamous Cell Carcinoma Progression
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers13010027
Abstract: Simple Summary Our study aimed to advance the understanding of vulvar squamous cell carcinoma (VSCC) biology by recognizing biological pathways that drive the progression of this disease. We applied the experimental path from global proteomic… read more here.
Keywords: carcinoma; squamous cell; vscc; biology ... See more keywords
Circulating MicroRNAs in Patients with Vulvar Squamous Cell Carcinoma and Its Precursors
Sign Up to like & getrecommendations! Published in 2024 at "Non-Coding RNA"
DOI: 10.3390/ncrna11010013
Abstract: Background/Objectives: Vulvar squamous cell carcinoma (VSCC) is a rare gynecologic malig-nancy, with most cases arising from differentiated vulvar intraepithelial neoplasia (dVIN). Ap-proximately one-third of VSCC cases originate from high-grade squamous intraepithelial lesions (HSIL), which are… read more here.
Keywords: circulating micrornas; vscc; squamous cell; cell carcinoma ... See more keywords
Biological implications of decoding the extracellular matrix of vulva cancer
Sign Up to like & getrecommendations! Published in 2024 at "Oncology Reports"
DOI: 10.3892/or.2024.8852
Abstract: The present review aimed to elucidate the roles of extracellular matrix (ECM) components in the progression of vulvar squamous cell carcinoma (VSCC) and explore potential therapeutic avenues for this type of malignancy. This exploration holds… read more here.
Keywords: cancer; matrix; extracellular matrix; implications decoding ... See more keywords