ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling
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DOI: 10.7554/elife.48576
Abstract: Upon membrane depolarization, the KCNQ1 potassium channel opens at the intermediate (IO) and activated (AO) states of the stepwise voltage-sensing domain (VSD) activation. In the heart, KCNQ1 associates with KCNE1 subunits to form IKs channels… read more here.
Keywords: vsd pore; pore coupling; state; vsd ... See more keywords