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   Articles with "vsmc" as a keyword



Matrix vesicles induce calcification of recipient vascular smooth muscle cells through multiple signaling pathways.

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recommendations! Published in 2018 at "Kidney international"

DOI: 10.1016/j.kint.2017.07.019

Abstract: In patients with chronic kidney and end-stage renal diseases, the major risk factor for progression of arterial calcification is the presence of existing (baseline) calcification. Here, we tested whether calcification of arteries is extended from… read more here.

Keywords: calcification recipient; vsmc; matrix vesicles; calcification ... See more keywords

The novel role of complement 3 in Wnt5a-mediated vascular smooth muscle cell calcification

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recommendations! Published in 2024 at "European Heart Journal"

DOI: 10.1093/eurheartj/ehae666.3893

Abstract: Although vascular calcification (VC) is a risk factor for cardiovascular and all-cause mortality, a therapy is not yet available. VC involves the transdifferentiation of vascular smooth muscle cells (VSMC) towards an osteochondrogenic lineage that results… read more here.

Keywords: calcium deposition; smooth muscle; wnt5a; jnk camkii ... See more keywords

Histone modification and chromosome remodeling regulate VSMC phenotypes in aging-associated aortic aneurysm

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recommendations! Published in 2025 at "Physiology"

DOI: 10.1152/physiol.2025.40.s1.1148

Abstract: Aortic aneurysm is a life-threatening vascular disease that has high morbidity and mortality after acute rupture. The development of aortic aneurysm involves the loss of vascular smooth muscle cells (VSMCs), extracellular matrix degradation, and inflammation.… read more here.

Keywords: physiology; contractile; ccar1; aortic aneurysm ... See more keywords

Qsox1 contributes to vascular remodelling in response to hypertension.

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recommendations! Published in 2025 at "Journal of vascular research"

DOI: 10.1159/000546331

Abstract: Abstract Introduction: QSOX1, a sulfhydryl oxidase involved in arterial remodelling, has recently emerged as a biomarker for preeclampsia and acute heart failure. This study sought the cardiovascular roles of Qsox1 in response to angiotensin II… read more here.

Keywords: qsox1 contributes; response; contributes vascular; qsox1 ... See more keywords

Abstract We0007: Transcriptional Profiling Identifies Bhlhe40 as a Key Regulator of Vascular Smooth Muscle Cell Phenotypic Modulation in Atherosclerosis

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recommendations! Published in 2025 at "Arteriosclerosis, Thrombosis, and Vascular Biology"

DOI: 10.1161/atv.45.suppl_1.we0007

Abstract: A defining feature of atherosclerosis is the uptake of oxidized lipids by cells, leading them to differentiate into foam cells. Foam cells were once believed to originate primarily from macrophages. However, recent research suggests that… read more here.

Keywords: vsmc derived; cell; foam cells; phenotypic modulation ... See more keywords

Abstract 1055: Atxn2 Inhibition Enhances The Contractile Phenotype Of Vascular Smooth Muscle Cells

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recommendations! Published in 2024 at "Arteriosclerosis, Thrombosis, and Vascular Biology"

DOI: 10.1161/atvb.44.suppl_1.1055

Abstract: Introduction: Phenotype switching of vascular smooth muscle cells (VSMC) between their synthetic and differentiated contractile state is a critical player in controlling the stability of atherosclerotic plaque. Hundreds of genes associated with coronary artery disease… read more here.

Keywords: atxn2 inhibition; smooth muscle; vsmc; contractile phenotype ... See more keywords

Abstract 3016: Cytoplasmic And Nuclear Nfatc3 Cooperatively Contributes To Vascular Smooth Muscle Cell Dysfunction And Drives Aortic Aneurysm And Dissection

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recommendations! Published in 2024 at "Arteriosclerosis, Thrombosis, and Vascular Biology"

DOI: 10.1161/atvb.44.suppl_1.3016

Abstract: Background: Aortic aneurysm and aortic dissection (AAD) are fatal diseases resulting in catastrophic aortic rupture and sudden death. The degradation of the extracellular matrix (ECM) and the phenotypic transformation of vascular smooth muscle cells (VSMCs)… read more here.

Keywords: nuclear nfatc3; vsmc; vsmc nfatc3; aortic aneurysm ... See more keywords

THO Complex-Dependent Posttranscriptional Control Contributes to Vascular Smooth Muscle Cell Fate Decision

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recommendations! Published in 2018 at "Circulation Research"

DOI: 10.1161/circresaha.118.313527

Abstract: Rationale: Modulation of vascular smooth muscle cell (VSMC) phenotype plays a fundamental role in vascular development and diseases. Although extensive studies uncovered the roles of transcriptional regulation in VSMC-specific gene expression, how posttranscriptional regulation contributes… read more here.

Keywords: vsmc; gene expression; expression; tho complex ... See more keywords

LncRNA PSR Regulates Vascular Remodeling Through Encoding a Novel Protein Arteridin

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recommendations! Published in 2022 at "Circulation Research"

DOI: 10.1161/circresaha.122.321080

Abstract: Rationale: Vascular smooth muscle cells (VSMCs) phenotype switch from contractile to proliferative phenotype is a pathological hallmark in various cardiovascular diseases. Recently, a subset of long noncoding RNAs was identified to produce functional polypeptides. However,… read more here.

Keywords: vsmc; phenotype switching; vascular remodeling; psr ... See more keywords

Vascular Smooth Muscle Cells: A Therapeutic Target in Atherosclerosis

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recommendations! Published in 2025 at "Reviews in Cardiovascular Medicine"

DOI: 10.31083/rcm28240

Abstract: Background: Vascular smooth muscle cells (VSMCs) are involved in atherosclerotic plaque development. The formation of VSMC-originated foam cells, phenotypic switching, and VSMC proliferation, migration, apoptosis, and autophagy play different roles in atherosclerosis (AS). Main Body:… read more here.

Keywords: proliferation migration; smooth muscle; vsmc; vascular smooth ... See more keywords

Large-conductance Ca2 +-activated K+ channel β1-subunit maintains the contractile phenotype of vascular smooth muscle cells

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recommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"

DOI: 10.3389/fcvm.2022.1062695

Abstract: Background Vascular smooth muscle cells (VSMCs) phenotype switching is very important during the pathogenesis and progression of vascular diseases. However, it is not well understood how normal VSMCs maintain the differentiated state. The large-conductance Ca2+-activated… read more here.

Keywords: vsmc; phenotype; vascular smooth; vsmcs ... See more keywords