The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1741202
Abstract: ABSTRACT Vascular smooth muscle cells (VSMCs) are an important source of foam cells in atherosclerosis. The mechanism for VSMC-derived foam cell formation is, however, poorly understood. Here, we demonstrate that the P2RY12/P2Y12 receptor is important… read more here.
Keywords: p2ry12 receptor; formation; vsmc derived; receptor ... See more keywords
Abstract We0007: Transcriptional Profiling Identifies Bhlhe40 as a Key Regulator of Vascular Smooth Muscle Cell Phenotypic Modulation in Atherosclerosis
Sign Up to like & getrecommendations! Published in 2025 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atv.45.suppl_1.we0007
Abstract: A defining feature of atherosclerosis is the uptake of oxidized lipids by cells, leading them to differentiate into foam cells. Foam cells were once believed to originate primarily from macrophages. However, recent research suggests that… read more here.
Keywords: vsmc derived; cell; foam cells; phenotypic modulation ... See more keywords