Translocator protein 18 kDa ligand alleviates neointimal hyperplasia in the diabetic rat artery injury model via activating PKG
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.02.015
Abstract: Aims: The proliferation of VSMCs is the pathologic basis for intimal hyperplasia after angioplasty in diabetic patients. Translocator protein (TSPO), located in the outer mitochondrial membrane, has been found to regulate redox intermediate components in… read more here.
Keywords: proliferation; translocator protein; vsmc proliferation; migration ... See more keywords
miRNAs through β-ARR2/p-ERK1/2 pathway regulate the VSMC proliferation and migration.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119703
Abstract: BACKGROUND miRNAs are involved in plaque formation of atherosclerosis and vessel restenosis. In this study, we investigated the effects of miR-599, miR-204, and miR-181b on VSMC proliferation, and migration through TGFβ receptor 2 (TGFβR2), β-arrestin… read more here.
Keywords: proliferation migration; vsmc proliferation; mir;
HMGB1 enhances AGE-mediated VSMC proliferation via an increase in 5-LO-linked RAGE expression.
Sign Up to like & getrecommendations! Published in 2019 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2019.04.001
Abstract: Receptors for advanced glycation end-product (RAGE) play a pivotal role in the progression of proliferative vascular diseases. However, the precise mechanisms regulating RAGE expression in vascular smooth muscle cells (VSMCs) of the injured vasculatures is… read more here.
Keywords: hmgb1; rage expression; age; vsmc proliferation ... See more keywords
Inhibition of miR-135a-5p attenuates vascular smooth muscle cell proliferation and vascular remodeling in hypertensive rats.
Sign Up to like & getrecommendations! Published in 2021 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-020-00608-x
Abstract: Proliferation of vascular smooth muscle cells (VSMCs) greatly contributes to vascular remodeling in hypertension. This study is to determine the roles and mechanisms of miR-135a-5p intervention in attenuating VSMC proliferation and vascular remodeling in spontaneously… read more here.
Keywords: proliferation; vsmc proliferation; shrs; vascular remodeling ... See more keywords
FAK in the nucleus prevents VSMC proliferation by promoting p27 and p21 expression via Skp2 degradation.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab132
Abstract: AIM Vascular smooth muscle cells (VSMCs) normally exhibit a very low proliferative rate. Vessel injury triggers VSMC proliferation, in part, through focal adhesion kinase (FAK) activation, which increases transcription of cyclin D1, a key activator… read more here.
Keywords: degradation; skp2; fak; proliferation ... See more keywords
Role of PCK2 in the proliferation of vascular smooth muscle cells in neointimal hyperplasia
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.75577
Abstract: Vascular smooth muscle cell (VSMC) proliferation is a hallmark of neointimal hyperplasia (NIH) in atherosclerosis and restenosis post-balloon angioplasty and stent insertion. Although numerous cytotoxic and cytostatic therapeutics have been developed to reduce NIH, it… read more here.
Keywords: proliferation; vsmc proliferation; neointimal hyperplasia; vascular smooth ... See more keywords