Oncolytic virotherapy enhances the efficacy of a cancer vaccine by modulating the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32325
Abstract: The efficacy of cancer vaccines has been limited by the immunosuppressive tumor microenvironment, which can be alleviated by immune checkpoint inhibitor (ICI) therapy. Here, we tested if oncolytic viruses (OVs), similar to ICI, can also… read more here.
Keywords: cancer; vsv; tumor microenvironment; efficacy cancer ... See more keywords
Comparison of Voxel S-Value Methods for Personalized Voxel-based Dosimetry of 177 Lu-DOTATATE.
Sign Up to like & getrecommendations! Published in 2022 at "Medical physics"
DOI: 10.1002/mp.15444
Abstract: PURPOSE Voxel-based dosimetry is potentially accurate than organ-based dosimetry because it considers the anatomical variations in each individual and the heterogeneous radioactivity distribution in each organ. Here, voxel-based dosimetry for 177 Lu-DOTATATE therapy was performed… read more here.
Keywords: vsv; based dosimetry; 177 dotatate; dosimetry ... See more keywords
Rapid Protection from COVID-19 in Nonhuman Primates Vaccinated Intramuscularly but Not Intranasally with a Single Dose of a Vesicular Stomatitis Virus-Based Vaccine
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03379-21
Abstract: The vesicular stomatitis virus (VSV) vaccine platform rose to fame in 2019, when a VSV-based Ebola virus (EBOV) vaccine was approved by the European Medicines Agency and the U.S. Food and Drug Administration for human… read more here.
Keywords: vsv; single dose; stomatitis virus; vesicular stomatitis ... See more keywords
Natural killer T cell immunotherapy combined with IL-15-expressing oncolytic virotherapy and PD-1 blockade mediates pancreatic tumor regression
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003923
Abstract: Background Pancreatic cancer is one of the leading causes of cancer death, with a 5-year -year survival rate of less than 10%. This results from late detection, high rates of metastasis, and resistance to standard… read more here.
Keywords: cell; nkt cell; vsv; cell activation ... See more keywords
Oncolytic Effect of a Recombinant Vesicular Stomatitis Virus Encoding a Tumor-suppressor MicroRNA in an Osteosarcoma Mouse Model
Sign Up to like & getrecommendations! Published in 2023 at "AntiCancer Research"
DOI: 10.21873/anticanres.16264
Abstract: Background/Aim: Attempts have been made to enhance treatment with vesicular stomatitis virus (VSV) for osteosarcoma. We have previously shown that VSV incorporated with miRNA143 enhanced the antitumor effect at some doses; however, the range of… read more here.
Keywords: osteosarcoma; vsv; effect; tumor suppressor ... See more keywords
Single-step rapid chromatographic purification and characterization of clinical stage oncolytic VSV-GP
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.992069
Abstract: Purification of viruses, especially for therapeutic purposes, is a tedious and challenging task. The challenges arise due to the size and surface complexity of the virus particles. VSV-GP is a promising oncolytic virus, which has… read more here.
Keywords: purification; vsv; single step; virus ... See more keywords
TLR7 Controls VSV Replication in CD169+ SCS Macrophages and Associated Viral Neuroinvasion
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00466
Abstract: Vesicular stomatitis virus (VSV) is an insect-transmitted rhabdovirus that is neurovirulent in mice. Upon peripheral VSV infection, CD169+ subcapsular sinus (SCS) macrophages capture VSV in the lymph, support viral replication, and prevent CNS neuroinvasion. To… read more here.
Keywords: vsv; tlr7; scs macrophages; infection ... See more keywords
Immunovirotherapy Based on Recombinant Vesicular Stomatitis Virus: Where Are We?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.898631
Abstract: Vesicular stomatitis virus (VSV), a negative-strand RNA virus of the Vesiculovirus genus, has demonstrated encouraging anti-neoplastic activity across multiple human cancer types. VSV is particularly attractive as an oncolytic agent because of its broad tropism,… read more here.
Keywords: stomatitis virus; vsv; immunovirotherapy based; vesicular stomatitis ... See more keywords
SARS-CoV-2 RBD protein enhances the oncolytic activity of the vesicular stomatitis virus
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1082191
Abstract: Despite recent advances in the research on oncolytic viruses (OVs), a better understanding of how to enhance their replication is key to improving their therapeutic index. Understanding viral replication is important to improve treatment outcomes… read more here.
Keywords: vsv; oncolytic activity; cov rbd; virus ... See more keywords
The Multiplicity of Infection of Recombinant Vaccinia Virus Expressing the T7 RNA Polymerase Determines the Rescue Efficiency of Vesicular Stomatitis Virus
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.846426
Abstract: Vesicular stomatitis virus (VSV) has a wide range of cell tropism, making it a prototype of studying the negative-strand RNA virus (NSRV), including virus–host interactions and vaccine development. Although VSV rescue systems have been progressively… read more here.
Keywords: stomatitis virus; vsv; rescue; vesicular stomatitis ... See more keywords
Effect of Constant Temperatures on Culicoides sonorensis Midge Physiology and Vesicular Stomatitis Virus Infection
Sign Up to like & getrecommendations! Published in 2022 at "Insects"
DOI: 10.3390/insects13040372
Abstract: Simple Summary Culicoides biting midges are nuisance pests of livestock and well-known vectors of veterinary arboviruses, such as vesicular stomatitis virus (VSV). Female midges ingest viruses when feeding on blood to obtain protein for egg-laying.… read more here.
Keywords: vsv; infection; vesicular stomatitis; physiology ... See more keywords