Refinement of the dopaminergic system of anuran amphibians based on connectivity with habenula, basal ganglia, limbic system, pallium, and spinal cord
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24793
Abstract: Whereas our understanding of the dopaminergic system in mammals allows for a distinction between ventral tegmental area (VTA) and substantia nigra pars compacta (SNc), no clear evidence for separate structures in anamniotes has been presented… read more here.
Keywords: vta; system; dopaminergic system; anuran amphibians ... See more keywords
Internet gaming disorder: deficits in functional and structural connectivity in the ventral tegmental area-Accumbens pathway
Sign Up to like & getrecommendations! Published in 2018 at "Brain Imaging and Behavior"
DOI: 10.1007/s11682-018-9929-6
Abstract: Dopamine projections from the ventral tegmental area (VTA) to the nucleus accumbens (NAc) and from the substantia nigra (SN) to the dorsal striatum are involved in addiction. However, relatively little is known about the implication… read more here.
Keywords: vta; functional structural; connectivity; structural connectivity ... See more keywords
The Resilient Phenotype Induced by Prophylactic Ketamine Exposure During Adolescence Is Mediated by the Ventral Tegmental Area–Nucleus Accumbens Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2021.05.002
Abstract: BACKGROUND Major depressive disorder is prevalent in children and adolescents and is associated with a high degree of morbidity throughout life, with potentially devastating personal consequences and public health impact. The efficacy of ketamine (KET)… read more here.
Keywords: phenotype; ket; vta; adolescence ... See more keywords
An atlas of transcriptionally defined cell populations in the rat ventral tegmental area.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110616
Abstract: The ventral tegmental area (VTA) is a complex brain region that is essential for reward function and frequently implicated in neuropsychiatric disease. While decades of research on VTA function have focused on dopamine neurons, recent… read more here.
Keywords: ventral tegmental; atlas transcriptionally; cell; vta ... See more keywords
Mechanisms of cannabinoid CB2 receptor-mediated reduction of dopamine neuronal excitability in mouse ventral tegmental area
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.03.040
Abstract: Background We have recently reported that activation of cannabinoid type 2 receptors (CB2Rs) reduces dopamine (DA) neuron excitability in mouse ventral tegmental area (VTA). Here, we elucidate the underlying mechanisms. Methods Patch-clamp recordings were performed… read more here.
Keywords: vta; reduction; excitability mouse; jwh133 ... See more keywords
Alpha1-adrenergic receptor blockade in the VTA modulates fear memories and stress responses
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.05.008
Abstract: Activity of the ventral tegmental area (VTA) and its terminals has been implicated in the Pavlovian associative learning of both stressful and rewarding stimuli. However, the role of the VTA noradrenergic signaling in fear responses… read more here.
Keywords: vta; alpha1 adrenergic; fear memories; adrenergic receptor ... See more keywords
Targeting histone deacetylation for recovery of maternal deprivation-induced changes in BDNF and AKAP150 expression in the VTA
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.08.002
Abstract: &NA; Severe early life stressors increase the probability of developing psychiatric disorders later in life through modifications in neuronal circuits controlling brain monoaminergic signaling. Our previous work demonstrated that 24 h maternal deprivation (MD) in… read more here.
Keywords: vta; maternal deprivation; levels vta; synaptic levels ... See more keywords
Prevalence of anxiety and risk associated with ventricular arrhythmia in patients with an implantable cardioverter defibrillator.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2020.02.005
Abstract: BACKGROUND Anxiety has been associated with adverse clinical outcomes in patients who have received an implantable cardioverter defibrillator (ICD). However, results are inconclusive likely due to different measures being used to assess anxiety. Hence, the… read more here.
Keywords: vta; risk; anxiety; analysis ... See more keywords
The activity of ventral tegmental area dopamine neurons during shock omission predicts safety learning.
Sign Up to like & getrecommendations! Published in 2022 at "Behavioral neuroscience"
DOI: 10.1037/bne0000506
Abstract: We studied the role of dopamine [tyrosine hydroxylase (TH)] neurons in the rat ventral tegmental area (VTA) in safety learning. First, we used an AX +/BX-discrimination procedure to establish conditioned stimulus (CS) B as a… read more here.
Keywords: safety; safety learning; dopamine neurons; vta ... See more keywords
Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2016.138
Abstract: The increase in dopamine (DA) neurotransmission stimulated by in vivo cocaine exposure is tempered by G protein-dependent inhibitory feedback mechanisms in DA neurons of the ventral tegmental area (VTA). G protein-gated inwardly rectifying K+ (GIRK/Kir3)… read more here.
Keywords: vta; effect; girk channels; cocaine ... See more keywords
NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28190-2
Abstract: Emotional stress is considered a severe pathogenetic factor of psychiatric disorders. However, the circuit mechanisms remain largely unclear. Using a three-chamber vicarious social defeat stress (3C-VSDS) model in mice, we here show that chronic emotional… read more here.
Keywords: induced anxiety; like behavior; stress; vta ... See more keywords