Selective vulnerability of ARID1A deficient colon cancer cells to combined radiation and ATR-inhibitor therapy
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DOI: 10.3389/fonc.2022.999626
Abstract: ARID1A is frequently mutated in colorectal cancer (CRC) cells. Loss of ARID1A function compromises DNA damage repair and increases the reliance of tumor cells on ATR-dependent DNA repair pathways. Here, we investigated the effect of… read more here.
Keywords: arid1a deficient; vulnerability arid1a; atr inhibitor; deficient ... See more keywords