Articles with "vulnerability nrf2" as a keyword



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Abstract PR16: A druggable transcriptional vulnerability in NRF2-dependent lung cancer

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Published in 2017 at "Molecular Cancer Therapeutics"

DOI: 10.1158/1538-8514.synthleth-pr16

Abstract: The b-ZIP transcription factor NRF2 is a master regulator of the cellular antioxidant response and frequently activated in Non-Small Cell Lung Cancers (NSCLCs). While direct pharmacological inhibition of NRF2 has proven challenging, its aberrant activation… read more here.

Keywords: vulnerability nrf2; nrf2 dependent; druggable transcriptional; lung ... See more keywords