ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma.
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DOI: 10.1016/j.cmet.2017.09.001
Abstract: Tumors undergo nutrient stress and need to reprogram their metabolism to survive. The stroma may play a critical role in this process by providing nutrients to support the epithelial compartment of the tumor. Here we… read more here.
Keywords: vulnerability p62; synthetic vulnerability; stroma; p62 deficient ... See more keywords