Evaluation of CHK1 activation in vulvar squamous cell carcinoma and its potential as a therapeutic target in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1638
Abstract: CHK1 is an important regulator of the cell cycle and DNA damage response, and its altered expression has been identified in various tumors. Chk1 inhibitors are currently being evaluated as monotherapy and as potentiators of… read more here.
Keywords: chk1; pchk1ser317 pchk1ser296; pchk1ser296 pchk1ser280; vulvar squamous ... See more keywords
Differential etiopathogenic features of vulvar squamous cell carcinomas in sub‐Saharan Africa and Europe
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34314
Abstract: Two pathways have been described for vulvar squamous cell carcinomas (VSCC), one associated with human papillomavirus (HPV), and the other HPV‐independent. We compared the etiopathogenic features of a series of VSCC from Mozambique, a sub‐Saharan… read more here.
Keywords: vulvar squamous; squamous cell; hpv; cell carcinomas ... See more keywords
Margin status revisited in vulvar squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2019.05.010
Abstract: OBJECTIVE To determine the incidence of local recurrence of vulvar squamous cell carcinoma in relation to tumor- and/or precursor lesion free pathologic margins. METHODS Consecutive patients with primary vulvar squamous cell carcinoma surgically treated in… read more here.
Keywords: carcinoma; squamous cell; local recurrence; vulvar squamous ... See more keywords
Potential targets for tumor-specific imaging of vulvar squamous cell carcinoma: A systematic review of candidate biomarkers.
Sign Up to like & getrecommendations! Published in 2020 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2019.12.030
Abstract: INTRODUCTION Vulvar squamous cell carcinoma (VSCC) is a rare malignancy with an increasing incidence, especially in young women. Surgical treatment of VSCC is associated with significant morbidity and high recurrence rates, which is related to… read more here.
Keywords: vscc; tumor specific; vulvar squamous; specific imaging ... See more keywords
Efficacy and safety of pembrolizumab for patients with previously treated advanced vulvar squamous cell carcinoma: Results from the phase 2 KEYNOTE-158 study.
Sign Up to like & getrecommendations! Published in 2022 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2022.01.029
Abstract: OBJECTIVE Treatment options for advanced vulvar cancer are limited. We evaluated pembrolizumab monotherapy in patients with advanced vulvar squamous cell carcinoma (SCC) enrolled in the phase 2 multicohort, open-label KEYNOTE-158 study (NCT02628067). METHODS Eligible patients… read more here.
Keywords: pembrolizumab; cell carcinoma; treatment; squamous cell ... See more keywords
Putative precancerous lesions of vulvar squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Seminars in diagnostic pathology"
DOI: 10.1053/j.semdp.2020.09.006
Abstract: Precursor lesions of vulvar squamous cell carcinoma (VSCC) can be divided into two major biologic and prognostic groups: HPV-associated and HPV-independent VSCC. These two pathways are categorized as usual vulvar intraepithelial neoplasia (uVIN) with progression… read more here.
Keywords: vulvar squamous; cell carcinoma; squamous cell; lesions vulvar ... See more keywords
Inguino-femoral radiotherapy in vulvar squamous cell carcinoma: clues to revised indications in patients with only one intracapsular lymph node metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Acta Oncologica"
DOI: 10.1080/0284186x.2019.1687934
Abstract: Abstract Background and objectives: The aim was to review the clinical impact of groin metastatic nodal disease in women with vulvar squamous cell carcinoma (VSCC) and to evaluate the impact of adjuvant radiotherapy on women… read more here.
Keywords: lymph node; cell carcinoma; metastasis; vulvar squamous ... See more keywords
Human papillomavirus (HPV)‐independent vulvar squamous cell carcinoma has a worse prognosis than HPV‐associated disease: a retrospective cohort study
Sign Up to like & getrecommendations! Published in 2017 at "Histopathology"
DOI: 10.1111/his.13205
Abstract: Vulvar squamous cell carcinoma (VSCC) can be subdivided by human papillomavirus (HPV) status into two clinicopathological entities. Studies on the prognostic significance of HPV in VSCC are discordant. read more here.
Keywords: cell carcinoma; squamous cell; papillomavirus hpv; hpv ... See more keywords
Positive surgical margin is an independent predictor of overall survival of patients with vulvar squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.14962
Abstract: It is uncertain whether curative surgical treatment or a less radical surgery with adjuvant treatment should be provided to preserve function in patients with vulvar squamous cell carcinoma (SCC) that is adjacent to the urethra,… read more here.
Keywords: cell carcinoma; squamous cell; surgical margin; vulvar squamous ... See more keywords
HLA‐G, HLA‐E, and IDO overexpression predicts a worse survival of Tunisian patients with vulvar squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "HLA"
DOI: 10.1111/tan.13536
Abstract: Little is known about non‐classical HLA molecules in vulvar squamous cell carcinoma (VSCC). Because of the indoleamine‐2,3‐dioxygenase (IDO) immune tolerant role in association with HLA‐G, we evaluated the clinical and prognostic value of HLA‐G, HLA‐E,… read more here.
Keywords: hla; hla ido; expression; hla hla ... See more keywords
Association of human papilloma virus status and response to radiotherapy in vulvar squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2019-000793
Abstract: Introduction Vulvar squamous cell carcinoma develops through two separate pathways, associated with the presence or absence of high-risk human papilloma virus (HPV). The objective of this study was to evaluate treatment response and clinical outcomes… read more here.
Keywords: vulvar squamous; cell carcinoma; squamous cell; hpv ... See more keywords