Laboratory misdiagnosis of von Willebrand disease in post‐menarchal females: A multi‐center study
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Hematology"
DOI: 10.1002/ajh.25869
Abstract: Increased awareness of von Willebrand Disease (VWD) has led to more frequent diagnostic laboratory testing, which insurers often dictate be performed at a facility with off‐site laboratory processing, instead of a coagulation facility with onsite… read more here.
Keywords: site; vwf; von willebrand; willebrand disease ... See more keywords
Thrombosis and von Willebrand Factor.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2016_122
Abstract: One of the key players in both hemostasis and thrombosis is von Willebrand factor (vWF), which demonstrates a duality between these two processes. Thrombus is structured by numerous elements, including endothelial cells, platelets, plasma proteins… read more here.
Keywords: vwf; thrombosis von; von willebrand; willebrand factor ... See more keywords
Laboratory Testing for von Willebrand Factor: Factor VIII Binding (for 2N VWD).
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7196-1_34
Abstract: Von Willebrand disease (VWD) is reportedly the most common inherited bleeding disorder and can also arise as an acquired syndrome (AVWS). These disorders develop due to defects and/or deficiency of the plasma protein von Willebrand… read more here.
Keywords: laboratory testing; von willebrand; willebrand factor; factor ... See more keywords
COVID-19 microthrombosis: unusually large VWF multimers are a platform for activation of the alternative complement pathway under cytokine storm
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Hematology"
DOI: 10.1007/s12185-022-03324-w
Abstract: ADAMTS13, a metalloproteinase, specifically cleaves unusually large multimers of von Willebrand factor (VWF), newly released from vascular endothelial cells. The ratio of ADAMTS13 activity to VWF antigen (ADAMTS13/VWF) and indicators of the alternative complement pathway… read more here.
Keywords: unusually large; activation; alternative complement; vwf ... See more keywords
Characterization of the von Willebrand factor/factor VIII complex produced by a novel purification process.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of pharmacal research"
DOI: 10.1007/s12272-020-01245-y
Abstract: Factor VIII (FVIII) is a blood coagulation protein that circulates as a complex with von Willebrand factor (vWF) in the plasma. In the survey of inhibitors in plasma product exposed toddlers (SIPPET) study, plasma-derived FVIII… read more here.
Keywords: purification; fviii; von willebrand; factor ... See more keywords
Von Willebrand factor antigen levels predict major adverse cardiovascular events in patients with carotid stenosis of the ICARAS study.
Sign Up to like & getrecommendations! Published in 2019 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2019.09.003
Abstract: BACKGROUND AND AIMS Von Willebrand factor (VWF) plays an important role in thrombogenesis and mediates platelet adhesion particularly under high shear stress. Such conditions are generally found in stenotic arteries and can eventually cause myocardial… read more here.
Keywords: carotid stenosis; von willebrand; cardiovascular events; patients carotid ... See more keywords
Biophysical Mechanisms of Von Willebrand Factor-Collagen Interactions
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2439
Abstract: Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that mediates platelet adhesion onto bleeding blood vessels by binding to both sub-endothelial collagen and platelets. VWF-collagen interactions are capable of resisting the substantial force imposed… read more here.
Keywords: collagen; collagen interactions; von willebrand; willebrand factor ... See more keywords
Mutation G1629E Increases von Willebrand Factor Cleavage via a Cooperative Destabilization Mechanism.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2016.11.3202
Abstract: The large multimeric glycoprotein von Willebrand Factor (VWF) plays a pivotal adhesive role during primary hemostasis. VWF is cleaved by the protease ADAMTS13 as a down-regulatory mechanism to prevent excessive VWF-mediated platelet aggregation. For each… read more here.
Keywords: mechanism; cleavage; von willebrand; vwf ... See more keywords
Dental invasive procedures in von Willebrand disease outpatients treated with high purity FVIII/VWF complex concentrate (Fanhdi®): experience of a single center
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e03426
Abstract: Purpose To retrospectively assess the effectiveness and safety of customized hemostatic protocols using a plasma-derived, von Willebrand Factor (VWF)-containing Factor VIII concentrate (pdVWF/FVIII) in von Willebrand disease (VWD) patients undergoing dental invasive procedures. Methods Protocol… read more here.
Keywords: dental invasive; disease; von willebrand; invasive procedures ... See more keywords
Upregulation of microRNA-195 ameliorates calcific aortic valve disease by inhibiting VWF via suppression of the p38-MAPK signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2020.01.001
Abstract: BACKGROUND Growing evidence has indicated that microRNAs (miRNAs) are involved in the progression of calcific aortic valve disease (CAVD), a progressive pathological condition with no effective pharmacological therapy. This study was set out with the… read more here.
Keywords: p38 mapk; mir 195; aortic valve; mapk signaling ... See more keywords
Arterial Pulsatility and Circulating von Willebrand Factor in Patients on Mechanical Circulatory Support.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.02.075
Abstract: BACKGROUND The main risk factor for bleeding in patients with continuous-flow mechanical circulatory support (CF-MCS) is the acquired von Willebrand factor (VWF) defect related to the high shear-stress forces developed by these devices. Although a… read more here.
Keywords: mcs; mechanical circulatory; pulsatility; model ... See more keywords