Effects of hydrophobicity, tethering and size on flow-induced activation of von Willebrand factor multimers.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2019.110050
Abstract: Von Willebrand factor (VWF) is a multimeric protein of blood plasma that mediates platelet adhesion to injury under strong hemodynamic flows in arterias and microvasvulature. We present a 3D coarse-grained computer model of VWF multimers… read more here.
Keywords: vwf multimers; von willebrand; activation; flow induced ... See more keywords
Inhibition of adamts13: a novel therapy to treat mechanical circulatory support-induced acquired von willebrand syndrome
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.3836
Abstract: Bleeding is the most frequent adverse event in patients with continuous flow mechanical circulatory support (CF-MCS) and has been linked to the occurrence of acquired von Willebrand syndrome (aVWS). MCS devices cause an increased shear-induced… read more here.
Keywords: impella; vwf multimers; von willebrand; hmw vwf ... See more keywords