Adult mouse eIF2Bε Arg191His astrocytes display a normal integrated stress response in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-21885-x
Abstract: Vanishing white matter (VWM) is a genetic childhood white matter disorder, characterized by chronic as well as episodic, stress provoked, neurological deterioration. Treatment is unavailable and patients often die within a few years after onset.… read more here.
Keywords: vwm; integrated stress; stress; stress response ... See more keywords
Isocaloric low protein diet in a mouse model for vanishing white matter does not impact ISR deregulation in brain, but reveals ISR deregulation in liver.
Sign Up to like & getrecommendations! Published in 2020 at "Nutritional neuroscience"
DOI: 10.1080/1028415x.2020.1846356
Abstract: Objective: Vanishing white matter (VWM) is a genetic brain white matter disorder caused by mutations in eIF2B. eIF2B is central in the integrated stress response (ISR), during which its activity is inhibited by various cellular… read more here.
Keywords: vwm; low protein; isr deregulation; deregulation ... See more keywords
Visual working memory in early development: a developmental cognitive neuroscience perspective.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of neurophysiology"
DOI: 10.1152/jn.00087.2018
Abstract: In this article, we review the literature on the development of visual working memory (VWM). We focus on two major periods of development, infancy and early childhood. First, we discuss the innovative methods that have… read more here.
Keywords: visual working; memory early; vwm; working memory ... See more keywords
Therapy Trial Design in Vanishing White Matter
Sign Up to like & getrecommendations! Published in 2022 at "Neurology: Genetics"
DOI: 10.1212/nxg.0000000000000657
Abstract: Vanishing white matter (VWM) is a leukodystrophy caused by recessive variants in the genes EIF2B1-EIF2B5. It is characterized by chronic neurologic deterioration with superimposed stress-provoked episodes of rapid decline. Disease onset spans from the antenatal… read more here.
Keywords: white matter; disease; vwm; trial ... See more keywords
I can look for it! Modulation of a concurrent Visual Working Memory task in Visual Search in development
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychology"
DOI: 10.3389/fpsyg.2022.907121
Abstract: Daily classroom activities that require children to perform visual search (VS) tasks are common across all educational levels: from searching for a missing piece of a puzzle in kindergarten to solving equations in college. However,… read more here.
Keywords: vwm; development; task; memory ... See more keywords