Divergent Construction of Spirocyclopentene-3,2'-indolines with Vicinal Stereocenters via Palladium-Catalyzed Aza-Wacker Cyclization.
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DOI: 10.1021/acs.orglett.5c00931
Abstract: Herein, we report an aerobic palladium-catalyzed aza-Wacker cyclization to produce spirocyclopentene-3,2'-indolines with vicinal stereocenters. Using 1,2-bis(diphenylphosphino)benzene (dppbz) and pyridine as ligands, we achieved a ligand-modulated diastereodivergent synthesis, producing cis- and trans-spirocyclopentene-3,2'-indolines with exceptional yields and… read more here.
Keywords: wacker cyclization; aza wacker; palladium catalyzed; spirocyclopentene indolines ... See more keywords