Influence of early social isolation on general activity and spatial learning in adult WAG/Rij rats.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental psychobiology"
DOI: 10.1002/dev.22319
Abstract: The study identifies the critical period of early ontogeny, during which social factors have the greatest influence on the operant behavior with positive reinforcement in adult WAG/Rij rats. Individual social isolation of rats from dam… read more here.
Keywords: general activity; adult wag; wag rij; isolation ... See more keywords
Investigating the mechanism of action of ginkgolides and bilobalide on absence seizures in male WAG/Rij rats
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25166
Abstract: The effects of a single and multiple doses of ginkgolide A, B, C, and bilobalide, active components of Ginkgo biloba extract (EGb 761), on absence seizures were investigated in male WAG/Rij rats, a genetic animal… read more here.
Keywords: absence seizures; male wag; absence; wag rij ... See more keywords
Fingolimod Exerts only Temporary Antiepileptogenic Effects but Longer-Lasting Positive Effects on Behavior in the WAG/Rij Rat Absence Epilepsy Model
Sign Up to like & getrecommendations! Published in 2017 at "Neurotherapeutics"
DOI: 10.1007/s13311-017-0550-y
Abstract: One of the major challenges in the epilepsy field is identifying disease-modifying drugs in order to prevent or delay spontaneous recurrent seizure onset or to cure already established epilepsy. It has been recently reported that… read more here.
Keywords: wag rij; absence epilepsy; antiepileptogenic effects;
Comparison of astrocytes and gap junction proteins in the white matter of genetic absence epileptic and control rats: an experimental study
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Research"
DOI: 10.1080/01616412.2022.2039527
Abstract: ABSTRACT Objectives The role of white matter astrocytes in absence epilepsy is unknown. The present study aims to quantify astrocytic markers glial fibrillary acidic protein (GFAP), gap junction’s proteins connexin 30 (Cx30) and connexin 43… read more here.
Keywords: gap junction; white matter; junction proteins; control ... See more keywords
The effect of quercetin on absence epilepsy in WAG/Rij rats.
Sign Up to like & getrecommendations! Published in 2023 at "Neurological research"
DOI: 10.1080/01616412.2023.2194182
Abstract: AIM In the present study, the effect of quercetin, a powerful antioxidant flavonoid, on genetic absence epilepsy was studied in WAG/Rij rats. MATERIAL AND METHOD Tripolar electrodes were implanted into WAG/Rij rats. Basal electrocorticography (ECoG)… read more here.
Keywords: absence; quercetin; effect quercetin; wag rij ... See more keywords
Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2021.766566
Abstract: Wistar Albino Glaxo Rijswijk (WAG/Rij) rats are widely used in basic and pre-clinical studies as a valid genetic model of absence epilepsy. Adult WAG/Rij rats exhibit generalized 8–10-Hz spike-wave discharges (SWDs) in the electroencephalogram. SWDs… read more here.
Keywords: epilepsy wag; wag rij; sleep; wave epilepsy ... See more keywords
Pain Modulation in WAG/Rij Epileptic Rats (A Genetic Model of Absence Epilepsy): Effects of Biological and Pharmacological Histone Deacetylase Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.549191
Abstract: Epigenetic mechanisms are involved in epilepsy and chronic pain development. About that, we studied the effects of the natural histone deacetylase (HDAC) inhibitor sodium butyrate (BUT) in comparison with valproic acid (VPA) in a validated… read more here.
Keywords: wag rij; epilepsy; genetic model; histone deacetylase ... See more keywords
Maternal Methyl-Enriched Diet Increases DNMT1, HCN1, and TH Gene Expression and Suppresses Absence Seizures and Comorbid Depression in Offspring of WAG/Rij Rats
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostics"
DOI: 10.3390/diagnostics13030398
Abstract: The reduced expression of the HCN1 ion channel in the somatosensory cortex (SSC) and mesolimbic dopamine deficiency are thought to be associated with the genesis of spike-wave discharges (SWDs) and comorbid depression in the WAG/Rij… read more here.
Keywords: dnmt1 hcn1; comorbid depression; wag rij; expression ... See more keywords