Activation of the GABAergic Parafacial Zone Maintains Sleep and Counteracts the Wake-Promoting Action of the Psychostimulants Armodafinil and Caffeine
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2017.152
Abstract: We previously reported that acute and selective activation of GABA-releasing parafacial zone (PZVgat) neurons in behaving mice produces slow-wave-sleep (SWS), even in the absence of sleep deficit, suggesting that these neurons may represent, at least… read more here.
Keywords: parafacial zone; wake promoting; pzvgat neurons; activation ... See more keywords
Rogdi Defines GABAergic Control of a Wake-promoting Dopaminergic Pathway to Sustain Sleep in Drosophila
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DOI: 10.1038/s41598-017-11941-3
Abstract: Kohlschutter-Tönz syndrome (KTS) is a rare genetic disorder with neurological dysfunctions including seizure and intellectual impairment. Mutations at the Rogdi locus have been linked to development of KTS, yet the underlying mechanisms remain elusive. Here… read more here.
Keywords: drosophila; rogdi; wake promoting; promoting dopaminergic ... See more keywords
Comparative Efficacy and Safety of Multiple Wake-Promoting Agents for the Treatment of Excessive Daytime Sleepiness in Narcolepsy: A Network Meta-Analysis
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DOI: 10.2147/nss.s404113
Abstract: Purpose Narcolepsy is a rare debilitating disorder for which multiple novel pharmacological options have been approved as treatment for the past few years. The current study systematically updates the comparative efficacy and detailed safety analysis… read more here.
Keywords: safety; comparative efficacy; efficacy; wake promoting ... See more keywords
The effects of diurnal intermittent fasting on the wake-promoting neurotransmitter orexin-A
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Thoracic Medicine"
DOI: 10.4103/atm.atm_181_17
Abstract: BACKGROUND: Food restriction has been demonstrated to increase the alertness in different species and to increase the levels of the wake-promoting neurotransmitter orexin. We hypothesized that diurnal intermittent fasting (DIF) increases orexin-A levels during fasting.… read more here.
Keywords: orexin; wake promoting; diurnal intermittent; neurotransmitter orexin ... See more keywords