To select or not to select? The role of B‐cell selection in determining the MYD88 mutation status in Waldenström Macroglobulinaemia
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DOI: 10.1111/bjh.13996
Abstract: Waldenstr€ om Macroglobulinaemia (WM) is a B-cell malignancy characterized by bone marrow (BM) infiltration with lymphoplasmacytic lymphoma and production of a monoclonal immunoglobulin (Ig) M protein (Owen et al, 2003). The tumour cell population in… read more here.
Keywords: myd88 l265p; cell; myd88; waldenstr macroglobulinaemia ... See more keywords
CXCR4 mutation subtypes impact response and survival outcomes in patients with Waldenström macroglobulinaemia treated with ibrutinib
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DOI: 10.1111/bjh.16088
Abstract: Ibrutinib is associated with response rate of 90% and median progression‐free survival (PFS) in excess of 5 years in Waldenström macroglobulinaemia (WM) patients. CXCR4 mutations are detected in 30–40% of patients with WM and associate… read more here.
Keywords: pfs; response; cxcr4 mutations; waldenstr macroglobulinaemia ... See more keywords
Inflammatory Waldenström's macroglobulinaemia: A French monocentric retrospective study of 67 patients
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DOI: 10.1111/bjh.18157
Abstract: Waldenström's macroglobulinaemia (WM) is a B‐cell neoplasm resulting from bone marrow lymphoplasmacytic infiltration and monoclonal IgM secretion. Some patients present concomitant inflammatory syndrome attributed to the disease activity; we named this syndrome inflammatory WM (IWM).… read more here.
Keywords: french monocentric; macroglobulinaemia french; inflammatory syndrome; waldenstr macroglobulinaemia ... See more keywords
Prognostic impact of MYD88 and CXCR4 mutations assessed by droplet digital polymerase chain reaction in IgM monoclonal gammopathy of undetermined significance and smouldering Waldenström macroglobulinaemia
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DOI: 10.1111/bjh.18502
Abstract: Waldenström macroglobulinaemia (WM) is characterized by recurrent somatic mutations in MYD88 and CXCR4 genes. However, limitations arise when analysing these mutations in IgM monoclonal gammopathy of undetermined significance (MGUS) or smouldering WM (SWM) given the… read more here.
Keywords: myd88; igm mgus; swm; cxcr4 ... See more keywords
Dose of ibrutinib in Waldenström macroglobulinaemia: Less can be more
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DOI: 10.1111/bjh.18664
Abstract: Ibrutinib changed the landscape of treatment in Waldenström macroglobulinaemia (WM) with excellent responses; however, there are high rates of dose reduction due to adverse events. The impact of this reduced dosing is unclear with regards… read more here.
Keywords: macroglobulinaemia less; dose ibrutinib; ibrutinib waldenstr; waldenstr macroglobulinaemia ... See more keywords
The Rory Morrison WMUK Registry for Waldenström macroglobulinaemia: The growth of a national registry for a rare disorder
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DOI: 10.1111/bjh.18680
Abstract: National registries are used globally to characterise patient demographics, treatment choices and mortality to inform and improve clinical management. Waldenström macroglobulinaemia (WM) is a rare, treatment‐responsive B‐cell lymphoproliferative disorder with diverse clinical features and variable… read more here.
Keywords: rory morrison; registry; disorder; waldenstr macroglobulinaemia ... See more keywords
Born in the UK: A registry to improve and broadcast knowledge on Waldenström macroglobulinaemia
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DOI: 10.1111/bjh.18695
Abstract: Registries constitute an interesting source of real‐world data and bring complementary information to randomised controlled trials. They are of particular importance in rare diseases such as Waldenström macroglobulinaemia (WM), which can present with various clinical… read more here.
Keywords: registry improve; improve broadcast; born registry; registry ... See more keywords