Amide-Directed Rhodium-Catalyzed Chain-Walking Hydrothiolation of Internal Alkenes.
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DOI: 10.1021/acs.orglett.4c00804
Abstract: We developed a rhodium-catalyzed chain-walking hydrothiolation process for internal alkenes, which offers a novel and efficient alternative for C(sp3)-H bond cleavage, while focusing on thiol incorporation. This method exclusively affords N,S-acetals at 36-90% yields. Regioconvergent… read more here.
Keywords: catalyzed chain; internal alkenes; rhodium catalyzed; walking hydrothiolation ... See more keywords