The ANK repeats of Notch-4/Int3 activate NF-κB canonical pathway in the absence of Rbpj and causes mammary tumorigenesis
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DOI: 10.1038/s41598-017-13989-7
Abstract: Transgenic mice expressing the Notch-4 intracellular domain (designated Int3) in the mammary gland have two phenotypes exhibited with 100% penetrance: arrest of mammary alveolar/lobular development and mammary tumorigenesis. Notch-4 signaling is mediated primarily through the… read more here.
Keywords: rbpj; wap int3; ank repeats; mammary tumorigenesis ... See more keywords