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   Articles with "wapl" as a keyword



The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension

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recommendations! Published in 2017 at "Cell"

DOI: 10.1016/j.cell.2017.04.013

Abstract: Summary The spatial organization of chromosomes influences many nuclear processes including gene expression. The cohesin complex shapes the 3D genome by looping together CTCF sites along chromosomes. We show here that chromatin loop size can… read more here.

Keywords: chromatin loop; cohesin; factor wapl; release factor ... See more keywords

Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl.

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recommendations! Published in 2017 at "Nature"

DOI: 10.1038/nature22063

Abstract: Mammalian genomes are spatially organized by CCCTC-binding factor (CTCF) and cohesin into chromatin loops and topologically associated domains, which have important roles in gene regulation and recombination. By binding to specific sequences, CTCF defines contact… read more here.

Keywords: mammalian genomes; cohesin; transcription ctcf; ctcf ... See more keywords

Molecular mechanism and functional significance of Wapl interaction with the Cohesin complex

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2405177121

Abstract: Significance The Cohesin complex is placed at the heart of many DNA-based processes including sister chromatid cohesion and chromatin loop extrusion. The Cohesin release factor Wapl opens the DNA exit gate in Cohesin rings to… read more here.

Keywords: mechanism functional; molecular mechanism; wapl; cohesin complex ... See more keywords

A kinase‐dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion

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recommendations! Published in 2018 at "EMBO reports"

DOI: 10.15252/embr.201744737

Abstract: Sister‐chromatid cohesion mediated by the cohesin complex is fundamental for precise chromosome segregation in mitosis. Through binding the cohesin subunit Pds5, Wapl releases the bulk of cohesin from chromosome arms in prophase, whereas centromeric cohesin… read more here.

Keywords: cohesin; centromere cohesion; cohesion; kinase dependent ... See more keywords