The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.04.013
Abstract: Summary The spatial organization of chromosomes influences many nuclear processes including gene expression. The cohesin complex shapes the 3D genome by looping together CTCF sites along chromosomes. We show here that chromatin loop size can… read more here.
Keywords: chromatin loop; cohesin; factor wapl; release factor ... See more keywords
Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl.
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature22063
Abstract: Mammalian genomes are spatially organized by CCCTC-binding factor (CTCF) and cohesin into chromatin loops and topologically associated domains, which have important roles in gene regulation and recombination. By binding to specific sequences, CTCF defines contact… read more here.
Keywords: mammalian genomes; cohesin; transcription ctcf; ctcf ... See more keywords
A kinase‐dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion
Sign Up to like & getrecommendations! Published in 2018 at "EMBO reports"
DOI: 10.15252/embr.201744737
Abstract: Sister‐chromatid cohesion mediated by the cohesin complex is fundamental for precise chromosome segregation in mitosis. Through binding the cohesin subunit Pds5, Wapl releases the bulk of cohesin from chromosome arms in prophase, whereas centromeric cohesin… read more here.
Keywords: cohesin; centromere cohesion; cohesion; kinase dependent ... See more keywords