An Unrevealed Molecular Function of Corannulene Buckybowl Glycoconjugates in Selective Tumor Annihilation by Targeting the Cancer‐Specific Warburg Effect
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105315
Abstract: The biomedical application of corannulene π‐bowls is historically limited by low solubility and bioavailability despite the potential in their unique electronic properties for new functional materials. Herein, the unexpected role and molecular mechanism of Corranulene… read more here.
Keywords: selective tumor; warburg effect; corannulene; tumor ... See more keywords
METTL5 stabilizes c‐Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Communications"
DOI: 10.1002/cac2.12403
Abstract: Hepatocellular carcinoma (HCC) is one of the most prevalent cancers in the world, with a high likelihood of metastasis and a dismal prognosis. The reprogramming of glucose metabolism is critical in the development of HCC.… read more here.
Keywords: glucose metabolism; hepatocellular carcinoma; hcc; warburg effect ... See more keywords
Energy balance‐related factors in childhood and adolescence and risk of colorectal cancer expressing different levels of proteins involved in the Warburg‐effect
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.33941
Abstract: Early‐life (childhood to adolescence) energy balance‐related factors (height, energy restriction, BMI) have been associated with adult colorectal cancer (CRC) risk. Warburg‐effect activation via PI3K/Akt‐signaling might explain this link. We investigated whether early‐life energy balance‐related factors… read more here.
Keywords: energy restriction; energy; warburg effect; colon cancer ... See more keywords
Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect
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DOI: 10.1002/iub.2668
Abstract: Cancer cells shift their glucose catabolism from aerobic respiration to lactic fermentation even in the presence of oxygen, and this is known as the “Warburg effect”. To accommodate the high glucose demands and to avoid… read more here.
Keywords: structural aspects; warburg effect; monocarboxylate transporters; aspects glucose ... See more keywords
Murburn precepts for lactic‐acidosis, Cori cycle, and Warburg effect: Interactive dynamics of dehydrogenases, protons, and oxygen
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DOI: 10.1002/jcp.30661
Abstract: It is unresolved why lactate is transported to the liver for further utilization within the physiological purview of Cori cycle, when muscles have more lactate dehydrogenase (LDH) than liver. We point out that the answer… read more here.
Keywords: protons oxygen; cori cycle; warburg effect; lactate ... See more keywords
The influence of photodynamic therapy on the Warburg effect in esophageal cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Lasers in Medical Science"
DOI: 10.1007/s10103-020-02966-8
Abstract: To investigate whether the Warburg effect is a key modulator on the resistance mechanism of photodynamic therapy (PDT). Glycolysis was examined by the test of lactate product and glucose uptake at different post-PDT time points.… read more here.
Keywords: esophageal cancer; glycolysis; effect; warburg effect ... See more keywords
Circular RNA hsa_circ_0091579 facilitates the Warburg effect and malignancy of hepatocellular carcinoma cells via the miR-624/H3F3B axis
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-021-02627-4
Abstract: Hepatocellular carcinoma (HCC) is a primary liver cancer with a high mortality rate. It has been reported that circular RNA hsa_circ_0091579 (circ_0091579) is involved in HCC progression. Nevertheless, the molecular mechanism by which circ_0091579 modulates… read more here.
Keywords: hcc; h3f3b; mir 624; warburg effect ... See more keywords
Regulating the Warburg effect on metabolic stress and myocardial fibrosis remodeling and atrial intracardiac waveform activity induced by atrial fibrillation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.06.055
Abstract: Atrial fibrillation (AF) is associated with metabolic stress and induces myocardial fibrosis reconstruction by increasing glycolysis. One goal in the treatment of paroxysmal AF (p-AF) is to improve myocardial fibrosis reconstruction and myocardial metabolic stress… read more here.
Keywords: fibrosis; metabolic stress; myocardial fibrosis; warburg effect ... See more keywords
ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
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DOI: 10.1016/j.canlet.2016.12.014
Abstract: Though significant progress has been made in the availability of diagnostic techniques and treatment strategies, pancreatic cancer remains a disease of high mortality rates. Therefore, there is an urgent need for a better understanding of… read more here.
Keywords: mutant kras; arf6; pancreatic cancer; warburg effect ... See more keywords
The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes
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DOI: 10.1016/j.celrep.2016.12.037
Abstract: SUMMARY Glioblastoma multiforme (GBM) is among the most aggressive of human cancers. Although differentiation therapy has been proposed as a potential approach to treat GBM, the mechanisms of induced differentiation remain poorly defined. Here, we… read more here.
Keywords: mitochondrial biogenesis; glioblastoma; pgc1 pathway; pgc1 ... See more keywords
Revisiting the Warburg Effect: Some Tumors Hold Their Breath.
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DOI: 10.1016/j.cmet.2018.10.011
Abstract: Studies have shown that tumors commonly exhibit normal or enhanced respiration in addition to glycolytic metabolism. In this issue, Courtney et al. (2018) report a reduction in mitochondrial function in kidney cancer patients and thus a… read more here.
Keywords: tumors hold; effect tumors; hold breath; warburg effect ... See more keywords