HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101218
Abstract: HSP60 is a major mitochondrial chaperone for maintaining mitochondrial proteostasis. Our previous studies showed that HSP60 was significantly downregulated in clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancer characterized by… read more here.
Keywords: biosynthesis; ccrcc; ccrcc cells; warburg like ... See more keywords
Microenvironmental cooperation promotes early spread and bistability of a Warburg-like phenotype
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DOI: 10.1038/s41598-017-03342-3
Abstract: We introduce an in silico model for the initial spread of an aberrant phenotype with Warburg-like overflow metabolism within a healthy homeostatic tissue in contact with a nutrient reservoir (the blood), aimed at characterizing the… read more here.
Keywords: phenotype; warburg like; tissue; microenvironmental cooperation ... See more keywords