Pharmacogenetic-guided and clinical warfarin dosing algorithm assessments with bleeding outcomes risk-stratified by genetic and covariate subgroups.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2020.03.055
Abstract: BACKGROUND Safe administration of warfarin presents challenges due to a narrow therapeutic INR range and significant variability in inter-individual dose response. Bleeding secondary to warfarin use is a leading cause of hospitalization. METHODS Five warfarin… read more here.
Keywords: inr target; warfarin; highly sensitive; pharmacogenetic guided ... See more keywords
Evaluating warfarin dosing models on multiple datasets with a novel software framework and evolutionary optimisation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biomedical informatics"
DOI: 10.1016/j.jbi.2020.103634
Abstract: Warfarin is an effective preventative treatment for arterial and venous thromboembolism, but requires individualised dosing due to its narrow therapeutic range and high individual variation. Many machine learning techniques have been demonstrated in this domain.… read more here.
Keywords: novel software; warfarin dosing; evaluating warfarin; software framework ... See more keywords
Genotype‐guided warfarin dosing vs. conventional dosing strategies: a systematic review and meta‐analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13621
Abstract: Previous trials on the effectiveness of genotype‐guided warfarin dosing vs. conventional dosing have been inconclusive. We conducted a systematic review and meta‐analysis of randomized trials comparing genotype‐guided to conventional dosing strategies. read more here.
Keywords: conventional dosing; guided warfarin; genotype guided; warfarin dosing ... See more keywords
Strategies for Equitable Pharmacogenomic-Guided Warfarin Dosing Among European and African American Individuals in a Clinical Population
Sign Up to like & getrecommendations! Published in 2017 at "Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing"
DOI: 10.1142/9789813207813_0050
Abstract: The blood thinner warfarin has a narrow therapeutic range and high inter- and intra-patient variability in therapeutic doses. Several studies have shown that pharmacogenomic variants help predict stable warfarin dosing. However, retrospective and randomized controlled… read more here.
Keywords: equitable pharmacogenomic; strategies equitable; african americans; population ... See more keywords