Low-dose Prothrombin Complex Concentrate for Warfarin-Associated Intracranial Hemorrhage with INR Less Than 2.0
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DOI: 10.1007/s12028-017-0422-7
Abstract: BackgroundProthrombin complex concentrates (PCCs) have become the first-line therapy for warfarin reversal in the setting of central nervous system (CNS) hemorrhage. Randomized, controlled studies comparing agents for warfarin reversal excluded patients with international normalized ratio… read more here.
Keywords: hemorrhage; inr; low dose; warfarin reversal ... See more keywords
Prothrombin Complex Concentrate for Warfarin Reversal in Patients with Continuous-Flow Left Ventricular Assist Devices: A Narrative Review
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DOI: 10.1097/mat.0000000000001021
Abstract: Supplemental Digital Content is available in the text. Durable left ventricular assist device (LVAD) recipients require long-term anticoagulation to prevent thromboembolic complications. Their management is complicated by the risk of bleeding, which may require rapid… read more here.
Keywords: reversal; pcc; warfarin reversal; ventricular assist ... See more keywords
Effect of vitamin K administration on rate of warfarin reversal
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DOI: 10.1111/trf.15146
Abstract: Vitamin K is reported to begin reversing warfarin within 6 to 12 hours, but this may occur sooner. We sought to determine the rate of international normalized ratio (INR) reversal following vitamin K and relationships… read more here.
Keywords: administration rate; effect vitamin; vitamin administration; rate ... See more keywords
Combination Therapy Using Prothrombin Complex Concentrate and Vitamin K in Anticoagulated Patients with Traumatic Intracranial Hemorrhage Prevents Progressive Hemorrhagic Injury: A Historically Controlled Study
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DOI: 10.2176/nmc.oa.2020-0252
Abstract: Warfarin remains crucially involved in the treatment of patients at thrombotic or thromboembolic risk. However, warfarin increases the mortality rate among patients with traumatic intracranial hemorrhage (TICH) through progressive hemorrhagic injury (PHI). Therefore, a rapid… read more here.
Keywords: combination; pcc; combination therapy; warfarin reversal ... See more keywords