Genetic analysis of VCP and WASH complex genes in a German cohort of sporadic ALS-FTD patients
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.04.023
Abstract: Mutations of the human valosin-containing protein, p97 (VCP) and Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex genes cause motor neuron and cognitive impairment disorders. Here, we analyzed a cohort of German patients with sporadic… read more here.
Keywords: analysis; complex genes; wash complex; wash ... See more keywords
The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.126462
Abstract: The evolutionary conserved Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex is one of the crucial multiprotein complexes that facilitates endosomal recycling of transmembrane proteins. Defects in WASH components have been associated with inherited developmental… read more here.
Keywords: hepatic wash; hdl cholesterol; wash complex; cholesterol ... See more keywords
Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.196758
Abstract: ABSTRACT Retromer and the associated actin-polymerizing WASH complex are essential for the endocytic recycling of a wide range of integral membrane proteins. A hereditary Parkinson's-disease-causing point mutation (D620N) in the retromer subunit VPS35 perturbs retromer's… read more here.
Keywords: retromer wash; interaction network; retromer; wash complex ... See more keywords
Mroh1, a lysosomal regulator localized by WASH-generated actin
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.197210
Abstract: ABSTRACT The steps leading to constitutive exocytosis are poorly understood. In Dictyostelium WASH complex mutants, exocytosis is blocked, so cells that take up fluorescent dextran from the medium retain it and remain fluorescent. Here, we… read more here.
Keywords: generated actin; wash complex; wash; wash generated ... See more keywords