Polysubstituted Pyrimidines as Potent Inhibitors of Prostaglandin E2 Production: Increasing Aqueous Solubility
Sign Up to like & getrecommendations! Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100263
Abstract: Water solubility is one of the key features of potential therapeutic agents. In order to enhance the low water solubility of the parent 5‐butyl‐4‐(4‐methoxyphenyl)‐6‐phenylpyrimidin‐2‐amine, a potent inhibitor of prostaglandin E2 (PGE2) production, we synthesized and… read more here.
Keywords: production; water solubility; solubility; parent ... See more keywords
A General Supramolecular Adjuvant for Pesticides Based on Host-Guest Recognition.
Sign Up to like & getrecommendations! Published in 2023 at "Pest management science"
DOI: 10.1002/ps.7492
Abstract: BACKGROUND Pesticides are indispensable in agriculture, and can effectively improve the yields and quality of crops. Due to their weak water solubility, most pesticides need to be dissolved by adding solubilizing adjuvants. In this work,… read more here.
Keywords: recognition; solubility; water solubility; supramolecular adjuvant ... See more keywords
Disruption of Phaffia rhodozyma cells and preparation of microencapsulated astaxanthin with high water solubility
Sign Up to like & getrecommendations! Published in 2018 at "Food Science and Biotechnology"
DOI: 10.1007/s10068-018-0443-9
Abstract: A novel process was developed for encapsulation of astaxanthin from Phaffia rhodozyma. The yeast cells were disrupted by glass beads and the high shearing force partially emulsified the astaxanthin in aqueous phase. The enzymolysis method… read more here.
Keywords: phaffia rhodozyma; water solubility;
Enhanced water solubility, stability, and in vitro antitumor activity of ferulic acid by chemical conjugation with amino-β-cyclodextrins
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Materials Science"
DOI: 10.1007/s10853-020-04621-7
Abstract: To improve the water solubility, stability and bioactivity of ferulic acid (FA), a series of conjugates (FA-NH-CD, FA-EDA-CD, and FA-HDA-CD) were synthesized by bonding FA with different amino-β-cyclodextrins (amino-β-CD, ACDs) through amidation reactions. The structures… read more here.
Keywords: water solubility; solubility; ferulic acid; stability ... See more keywords
The effect of zeolite incorporation on the physical properties of silver-reinforced glass ionomer cement
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Materials Science: Materials in Medicine"
DOI: 10.1007/s10856-022-06659-2
Abstract: Zeolite can impart antibacterial properties to dental materials in the long-term when incorporated with inorganic cations. However, due to its porosity, it may jeopardize the mechanical integrity of the dental material. The aim of this… read more here.
Keywords: water solubility; reinforced glass; water; physical properties ... See more keywords
Construction of cinnamic acids derived β-cyclodextrins and their emodin-based inclusions with enhanced water solubility, excellent antioxidant and antibacterial activities
Sign Up to like & getrecommendations! Published in 2020 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"
DOI: 10.1016/j.colsurfa.2020.125382
Abstract: Abstract β-Cyclodextrin (β-CD) is a natural macromolecule which has been regarded as a promising biomaterial and drug carrier. However, the poor water solubility and less functions of β-CD severely hinder its potential applications. Herein, we… read more here.
Keywords: ads inclusions; enhanced water; water solubility; water ... See more keywords
Opening NADPH oxidase inhibitors for in vivo translation
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2017.03.001
Abstract: &NA; Triazolopyrimidine derivatives from the VAS library have been found to be efficient and selective NADPH oxidase (NOX) inhibitors in vitro. In spite of numerous publications on this compound class detailing efficacy for the treatment… read more here.
Keywords: water solubility; vivo translation; translation; nadph oxidase ... See more keywords
Dermal flurbiprofen nanosuspensions: Optimization with design of experiment approach and in vitro evaluation
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.07.009
Abstract: &NA; Flurbiprofen (FB) is the one of the non‐steroidal anti‐inflammatory drugs (NSAIDs) which has low water solubility and dissolution. Nanosuspensions are promising drug delivery systems consisting pure drug particles to overcome poor water solubility issues.… read more here.
Keywords: water solubility; design experiment; solubility; vitro ... See more keywords
Fabrication and characterization of zein/lactoferrin composite nanoparticles for encapsulating 7,8-dihydroxyflavone: Enhancement of stability, water solubility and bioaccessibility.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.12.251
Abstract: 7,8-dihydroxyflavone (7,8-DHF), a tyrosine kinase B (TrkB) receptor agonist, can mimick physiological actions of brain-derived neurotrophic factor (BDNF) to attenuate neurogenic disease. However, its use as a functional food, is limited by its low-water solubility,… read more here.
Keywords: zein; stability; zein nanoparticles; water solubility ... See more keywords
Bulgur bran as a biopolymer source: Production and characterization of nanocellulose-reinforced hemicellulose-based biodegradable films with decreased water solubility
Sign Up to like & getrecommendations! Published in 2021 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2021.113847
Abstract: Abstract Bulgur bran is a lignocellulosic side-stream of bulgur production factories. Separation of bulgur bran into cellulose- and hemicellulose-rich fractions paved the way of utilization of this under-exploited agro-industrial biomass. Although hemicellulose-based biodegradable food packaging… read more here.
Keywords: hemicellulose based; water solubility; bulgur bran; water ... See more keywords
Prediction of water solubility and Setschenow coefficients by tree-based regression strategies
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2019.03.029
Abstract: Abstract The experimental determination of water solubility (log S0) and Setschenow coefficient (km) of a compound is a time-consuming activity, which often needs large amounts of expensive substances. This work aims at establishing two “open-source”… read more here.
Keywords: based regression; water solubility; setschenow coefficients; water ... See more keywords