A conformational change within the WAVE2 complex regulates its degradation following cellular activation
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep44863
Abstract: WASp family Verprolin-homologous protein-2 (WAVE2), a member of the Wiskott-Aldrich syndrome protein (WASp) family of actin nucleation promoting factors, is a central regulator of actin cytoskeleton polymerization and dynamics. Multiple signaling pathways operate via WAVE2… read more here.
Keywords: protein; degradation; wave2; conformational change ... See more keywords
WAVE1 and WAVE2 have distinct and overlapping roles in controlling actin assembly at the leading edge
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e19-12-0705
Abstract: SCAR/WAVE proteins and Arp2/3 complex assemble branched actin networks at the leading edge. Two isoforms of SCAR/WAVE, WAVE1 and WAVE2, reside at the leading edge, yet it has remained unclear whether they perform similar or… read more here.
Keywords: wave2; actin; leading edge; roles controlling ... See more keywords
WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity
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DOI: 10.1126/science.aaz4544
Abstract: WAVE-ing T cell activation off The WAVE regulatory complex (WRC) is a pentameric complex that regulates actin cytoskeleton dynamics. The precise role for the WRC in immunity has not been established, although recent work has… read more here.
Keywords: wave2; mtor; mtor activation; mice ... See more keywords
WAVE2 Enhanced Hepatic Stellate Cells Activity in Colorectal Liver Metastases
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Management and Research"
DOI: 10.2147/cmar.s259125
Abstract: Background Cancer cell migration, tumor angiogenesis, and activated hepatic stellate cells (a-HSCs) promote the development of colorectal liver metastases (CLM). Wiskott–Aldrich syndrome protein family verprolin-homologous protein 2 (WAVE2) has been associated with CLM, although the… read more here.
Keywords: wave2; clm; colorectal liver; hepatic stellate ... See more keywords
The Role of WAVE2 Signaling in Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9091217
Abstract: The Wiskott–Aldrich syndrome protein (WASP) and WASP family verprolin-homologous protein (WAVE)—WAVE1, WAVE2 and WAVE3 regulate rapid reorganization of cortical actin filaments and have been shown to form a key link between small GTPases and the… read more here.
Keywords: wave2; family; role; cancer ... See more keywords