Four‐Way Crossover Phase 1 Thorough QT Study to Assess Cardiac Safety of Domperidone and Consideration for Design and Conduct of QT/QTc Study in China
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DOI: 10.1002/cpdd.1072
Abstract: This study aimed to evaluate the QT prolongation potential of domperidone in healthy Chinese participants and explore the possibility of a thorough QT (TQT) study in China with a smaller sample size using concentration‐QT (C‐QT)… read more here.
Keywords: domperidone placebo; way crossover; domperidone; study china ... See more keywords
Thiopurines with low-dose allopurinol (ThiLDA)—a prospective clinical one-way crossover trial
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DOI: 10.1007/s00228-019-02760-8
Abstract: Many patients with Crohn’s disease (CD) and ulcerative colitis (UC) who have a high 6-methylmercaptopurine/6-thioguanine (6-MMP/6-TGN) ratio receive allopurinol 100 mg in addition to thiopurines to optimize metabolite concentrations. However, some patients do not tolerate… read more here.
Keywords: way crossover; allopurinol; metabolite concentrations; one way ... See more keywords
Solithromycin, a novel macrolide, does not prolong cardiac repolarization: a randomized, three-way crossover study in healthy subjects
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DOI: 10.1093/jac/dkw428
Abstract: Background Macrolide antibiotics may cause QT prolongation. Objectives To study the QT effect of a novel macrolide, solithromycin. Methods This was a thorough QT study with a three-way crossover design performed in healthy male and… read more here.
Keywords: solithromycin; three way; study; novel macrolide ... See more keywords