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Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1072
Abstract: This study aimed to evaluate the QT prolongation potential of domperidone in healthy Chinese participants and explore the possibility of a thorough QT (TQT) study in China with a smaller sample size using concentration‐QT (C‐QT)…
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Keywords:
domperidone placebo;
way crossover;
domperidone;
study china ... See more keywords
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Published in 2019 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-019-02760-8
Abstract: Many patients with Crohn’s disease (CD) and ulcerative colitis (UC) who have a high 6-methylmercaptopurine/6-thioguanine (6-MMP/6-TGN) ratio receive allopurinol 100 mg in addition to thiopurines to optimize metabolite concentrations. However, some patients do not tolerate…
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Keywords:
way crossover;
allopurinol;
metabolite concentrations;
one way ... See more keywords
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Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkw428
Abstract: Background Macrolide antibiotics may cause QT prolongation. Objectives To study the QT effect of a novel macrolide, solithromycin. Methods This was a thorough QT study with a three-way crossover design performed in healthy male and…
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Keywords:
solithromycin;
three way;
study;
novel macrolide ... See more keywords