A cost-effective detection of low-abundance mutation with DNA three-way junction structure and lambda exonuclease
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2020.06.009
Abstract: ABSTRACT We presented a low-abundance mutation detection method with lambda exonuclease and DNA three-way junction structure. The assistant strand in the DNA three-way junction structure could regulate the reaction system from the kinetics and thermodynamics… read more here.
Keywords: three way; dna three; structure; junction structure ... See more keywords
A three-way junction structure-based isothermal exponential amplification strategy for sensitive detection of 3'-terminal 2'-O-methylated plant microRNA.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c6cc08726d
Abstract: Plant microRNAs (miRNAs) differ from animal miRNAs in that they are 2'-O-methylated at the 3' end nucleotide which limits the ability of plant miRNAs to serve as primers for polymerization reactions. Herein, we have rationally… read more here.
Keywords: plant; three way; structure based; junction structure ... See more keywords
Impact of the structural integrity of the three-way junction of adenovirus VAI RNA on PKR inhibition
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DOI: 10.1371/journal.pone.0186849
Abstract: Highly structured RNA derived from viral genomes is a key cellular indicator of viral infection. In response, cells produce the interferon inducible RNA-dependent protein kinase (PKR) that, when bound to viral dsRNA, phosphorylates eukaryotic initiation… read more here.
Keywords: pkr; inhibition; way junction; three way ... See more keywords
Folding Free Energy Determination of an RNA Three-Way Junction Using Fluctuation Theorems
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DOI: 10.3390/e24070895
Abstract: Nonequilibrium work relations and fluctuation theorems permit us to extract equilibrium information from nonequilibrium measurements. They find application in single-molecule pulling experiments where molecular free energies can be determined from irreversible work measurements by using… read more here.
Keywords: fluctuation; way junction; three way; fluctuation theorems ... See more keywords