Naturally occurring three-way junctions can be repurposed as genetically encoded RNA-based sensors.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.04.022
Abstract: Small molecules can be imaged in living cells using biosensors composed of RNA. However, RNA-based devices are difficult to design. Here, we describe a versatile platform for designing RNA-based fluorescent small-molecule sensors using naturally occurring… read more here.
Keywords: way junctions; three way; rna based; naturally occurring ... See more keywords
Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02874c
Abstract: Non-canonical DNA structures, particularly 3-Way Junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target 3WJs that relies on the cooperative… read more here.
Keywords: dna; selective recognition; three fold; fold symmetric ... See more keywords