LAUSR

1245. In Vivo Efficacy of WCK 4282 (High Dose Cefepime [FEP]-Tazobactam [TZB]) Against β-Lactamase-Producing (BLP) Gram-Negative Bacteria in a Neutropenic Murine Pneumonia Model

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1 Published in 2020 at "Open Forum Infectious Diseases"

DOI: 10.1093/ofid/ofaa439.1430

Abstract: Carbapenems are often used for Extended-Spectrum β-lactamase (ESBL)- and cephalosporinase (AmpC or CMY)-producing infections. Their increased use resulted in the emergence of carbapenem resistance among Gram-negatives, promoting the need of an effective carbapenem-sparing option. WCK… read more here.

Keywords: fep; wck 4282; pneumonia model; wck ... See more keywords

725. WCK 5222 (Cefepime/Zidebactam): An In Vitro Assessment of Activity Compared with Current Dual-Antibiotic Options Against Multidrug-Resistant Pseudomonas aeruginosa

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0 Published in 2019 at "Open Forum Infectious Diseases"

DOI: 10.1093/ofid/ofz360.793

Abstract: Abstract Background Pseudomonas aeruginosa (PSA) is an opportunistic pathogen known to cause complications in critically ill patients worldwide. In those at risk of infection with multidrug-resistant strains (MDR-PSA), dual antibiotic therapy is often considered. However,… read more here.

Keywords: cefepime; susceptibility; wck 5222; wck ... See more keywords

In Vivo Efficacy of WCK 5222 (Cefepime-Zidebactam) against Multidrug-Resistant Pseudomonas aeruginosa in the Neutropenic Murine Thigh Infection Model

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0 Published in 2019 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.00233-19

Abstract: We describe the in vivo efficacy of human-simulated WCK 5222 (cefepime-zidebactam) exposure against multidrug-resistant Pseudomonas aeruginosa (meropenem MICs 8 to >256 μg/ml) in a neutropenic murine thigh infection model. WCK 5222 MICs ranged from 4 to… read more here.

Keywords: wck; cefepime zidebactam; vivo efficacy; 5222 cefepime ... See more keywords

Molecular Characterization of WCK 5222 (Cefepime/Zidebactam)-Resistant Mutants Developed from a Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolate

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1 Published in 2022 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.02678-21

Abstract: Antibiotic resistance imposes a severe threat on human health. WCK 5222 is a β-lactam/β-lactamase inhibitor combination that is composed of cefepime and zidebactam. ABSTRACT WCK 5222 (cefepime/zidebactam) is a β-lactam/β-lactamase inhibitor combination that is effective… read more here.

Keywords: wck 5222; wck; resistant pseudomonas; resistance ... See more keywords