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Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.105863
Abstract: Cefepime/zidebactam (WCK 5222), a β-lactam/β-lactam enhancer antibiotic under development, was designed to retain in vitro activity against Enterobacteriaceae that simultaneously produce metallo-β-lactamase (MBL) and serine-β-lactamase (SBL). Currently, aztreonam (ATM) plus ceftazidime/avibactam (CZA) or meropenem/vaborbactam (M/V)…
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Keywords:
cefepime;
vitro activity;
cza atm;
wck 5222 ... See more keywords
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Published in 2019 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofz360.793
Abstract: Abstract Background Pseudomonas aeruginosa (PSA) is an opportunistic pathogen known to cause complications in critically ill patients worldwide. In those at risk of infection with multidrug-resistant strains (MDR-PSA), dual antibiotic therapy is often considered. However,…
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Keywords:
cefepime;
susceptibility;
wck 5222;
wck ... See more keywords
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Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00233-19
Abstract: We describe the in vivo efficacy of human-simulated WCK 5222 (cefepime-zidebactam) exposure against multidrug-resistant Pseudomonas aeruginosa (meropenem MICs 8 to >256 μg/ml) in a neutropenic murine thigh infection model. WCK 5222 MICs ranged from 4 to…
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Keywords:
wck;
cefepime zidebactam;
vivo efficacy;
5222 cefepime ... See more keywords
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Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01669-19
Abstract: The in vitro activity of WCK 5222 (cefepime-zidebactam) was compared to that of several available combination therapies among 30 clinical carbapenem-resistant Pseudomonas aeruginosa (CRP) strains using gradient diffusion strips. The combinations included nonsusceptible β-lactams (cefepime,…
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Keywords:
resistant pseudomonas;
cefepime zidebactam;
5222 cefepime;
carbapenem resistant ... See more keywords
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Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02678-21
Abstract: Antibiotic resistance imposes a severe threat on human health. WCK 5222 is a β-lactam/β-lactamase inhibitor combination that is composed of cefepime and zidebactam. ABSTRACT WCK 5222 (cefepime/zidebactam) is a β-lactam/β-lactamase inhibitor combination that is effective…
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Keywords:
wck 5222;
wck;
resistant pseudomonas;
resistance ... See more keywords