WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10794-w
Abstract: Cancer cells secrete matrix metalloproteinases to remodel the extracellular matrix, which enables them to overcome tissue barriers and form metastases. The membrane-bound matrix metalloproteinase MT1-MMP (MMP14) is internalized by endocytosis and recycled in endosomal compartments.… read more here.
Keywords: secretion; matrix metalloproteinase; mt1 mmp; vamp3 dependent ... See more keywords
Overexpression of WDFY2 inhibits prostate cancer cell growth and migration via inactivation of Akt pathway
Sign Up to like & getrecommendations! Published in 2017 at "Tumor Biology"
DOI: 10.1177/1010428317704821
Abstract: Prostate cancer is the most commonly diagnosed malignancy and is the second leading deadly reason among male cancer. WDFY2, which is found to be a cancer-specific fusion gene with CDKN2D in ovarian cancer, is a… read more here.
Keywords: cancer; wdfy2; prostate cancer; cancer cell ... See more keywords
CORRIGENDUM to “Overexpression of WDFY2 inhibits prostate cancer cell growth and migration via inactivation of Akt pathway”
Sign Up to like & getrecommendations! Published in 2020 at "Tumor Biology"
DOI: 10.1177/1010428320970884
Abstract: Figure 3. Overexpression of WDFY2 suppressed the colony formation and migration ability of prostate cancer cells. (a) Western blot showed the establishment of WDFY2 stably expressed cell lines in DU145 and PC-3. (b) Representative results… read more here.
Keywords: transfected control; control vector; migration; cells transfected ... See more keywords