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   Articles with "wdr5" as a keyword



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MLL/WDR5 Complex Regulates Kif2A Localization to Ensure Chromosome Congression and Proper Spindle Assembly during Mitosis.

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recommendations! Published in 2017 at "Developmental cell"

DOI: 10.1016/j.devcel.2017.05.023

Abstract: Mixed-lineage leukemia (MLL), along with multisubunit (WDR5, RbBP5, ASH2L, and DPY30) complex catalyzes the trimethylation of H3K4, leading to gene activation. Here, we characterize a chromatin-independent role for MLL during mitosis. MLL and WDR5 localize… read more here.

Keywords: mitosis; mll complex; mll; localization ... See more keywords
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Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction.

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recommendations! Published in 2023 at "ACS chemical biology"

DOI: 10.1021/acschembio.2c00843

Abstract: WD repeat domain 5 (WDR5) is a member of the WD40-repeat protein family that plays a critical role in multiple processes. It is also a prominent target for pharmacological inhibition in diseases such as cancer,… read more here.

Keywords: interaction; wdr5; discovery potent; molecule ... See more keywords

WDR5 is a prognostic biomarker of brain metastasis from non-small cell lung cancer

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recommendations! Published in 2022 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2022.1023776

Abstract: Background Lung cancer (LC) is the most frequent caner type and causes the most cancer-related death. Brain metastases (BM) are the deadliest complications of lung cancer, and the prognostic biomarkers of BM are urgently needed.… read more here.

Keywords: prognostic biomarker; wdr5; lung cancer; cancer ... See more keywords
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Inhibition of Wdr5 Attenuates Ang-II-Induced Fibroblast-to-Myofibroblast Transition in Cardiac Fibrosis by Regulating Mdm2/P53/P21 Pathway

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recommendations! Published in 2022 at "Biomolecules"

DOI: 10.3390/biom12111574

Abstract: Cardiac fibrosis is an important pathological process in many diseases. Wdr5 catalyzes the trimethylation of lysine K4 on histone H3. The effects of Wdr5 on the cardiac fibrosis phenotype and the activation or transformation of… read more here.

Keywords: wdr5; inhibition wdr5; cardiac fibrosis; cardiac fibroblasts ... See more keywords