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Published in 2018 at "Cold Spring Harbor protocols"
DOI: 10.1101/pdb.prot099960
Abstract: Many molecules can be made more immunogenic by denaturation. This treatment will change the structure of many compounds, particularly proteins, and expose new epitopes. In addition, heating will often cause protein antigens to aggregate, and,…
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Keywords:
protein antigens;
antigens strong;
denaturation;
making weak ... See more keywords
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1
Published in 2021 at "Cold Spring Harbor protocols"
DOI: 10.1101/pdb.prot099978
Abstract: If antibodies against a particular antigen are available, that antigen can be purified and used for further immunizations, and antigens thus purified can show enhanced immunogenicity. Purified immune complexes can be injected directly, or while…
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Keywords:
immune complexes;
strong preparing;
antigens strong;
weak antigens ... See more keywords
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Published in 2018 at "Cold Spring Harbor protocols"
DOI: 10.1101/pdb.prot100016
Abstract: Haptens, which are small antigens such as peptides and drug compounds, are very weakly or nonimmunogenic by themselves and require the assistance of carrier proteins: complex molecules capable of eliciting a strong immune response in…
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Keywords:
antigens strong;
strong cross;
weak antigens;
making weak ... See more keywords