Flotillin-2 dampens T cell antigen sensitivity and functionality
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DOI: 10.1172/jci.insight.182328
Abstract: T cell receptor (TCR) engagement triggers T cell responses, yet how TCR-mediated activation is regulated at the plasma membrane remains unclear. Here, we report that deleting the membrane scaffolding protein Flotillin-2 (Flot2) increases T cell… read more here.
Keywords: antigen sensitivity; weak tcr; cell; sensitivity ... See more keywords