Weakly Basic Anion Recognition by Naphthalenediimide‐Based Polymer
Sign Up to like & getrecommendations! Published in 2017 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.201700333
Abstract: The development of naphthalenediimide (NDI)-based sensors for weakly basic anion recognition is an attractive challenge. This paper presents an NDI-based polymer for the recognition of weakly basic oxyanions (AcO−, PhCO2−, ClO4−, and IO4−) and halides… read more here.
Keywords: based polymer; basic anion; recognition; weakly basic ... See more keywords
Water-dispersible and quasi-superparamagnetic magnetite nanoparticles prepared in a weakly basic solution at the low synthetic temperature
Sign Up to like & getrecommendations! Published in 2018 at "Materials Research Bulletin"
DOI: 10.1016/j.materresbull.2018.04.059
Abstract: Abstract Magnetite nanoparticles were prepared in a weakly basic solution at the low reaction temperature by the co-precipitation method. As a comparison, the oxidative precipitation method was also applied in this study. The structure, morphology,… read more here.
Keywords: prepared weakly; magnetite nanoparticles; basic solution; weakly basic ... See more keywords
Structure-activity relationships studies on weakly basic N-arylsulfonylindoles with an antagonistic profile in the 5-HT 6 receptor
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2017.03.067
Abstract: Abstract We recently reported a series of 39 weakly basic N -arylsulfonylindoles as novel 5-HT 6 antagonists. Eight of the compounds exhibited moderate to high binding affinities, with 2-(4-(2-Methoxyphenyl)piperazin-1-yl)-1-(1-tosyl-1 H -indol-3-yl)ethanol 16 showing the highest… read more here.
Keywords: activity relationships; structure activity; weakly basic; basic arylsulfonylindoles ... See more keywords
Phase Behavior and Crystallization Kinetics of a Poorly Water-Soluble Weakly Basic Drug as a Function of Supersaturation and Media Composition.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00927
Abstract: Understanding the supersaturation and precipitation behavior of poorly water-soluble compounds in vivo and the impact on oral absorption is critical to design consistently performing products with optimized bioavailability. Weakly basic compounds are of particular importance… read more here.
Keywords: poorly water; phase; supersaturation; weakly basic ... See more keywords
Dissolution Behavior of Weakly Basic Pharmaceuticals from Amorphous Dispersions Stabilized by a Poly(dimethylaminoethyl Methacrylate) Copolymer.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00456
Abstract: Amorphous solid dispersions (ASDs) are a well-documented formulation approach to improve the rate and extent of dissolution for hydrophobic pharmaceuticals. However, weakly basic compounds can complicate standard approaches to ASDs due to pH-dependent solubility, resulting… read more here.
Keywords: eudragit epo; dissolution behavior; amorphous dispersions; dissolution ... See more keywords
Use of Gastrointestinal Simulator, Mass Transport Analysis, and Absorption Simulation to Investigate the Impact of pH Modifiers in Mitigating Weakly Basic Drugs' Performance Issues Related to Gastric pH: Palbociclib Case Study.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00545
Abstract: It is well known that reduced gastric acidity, for example with concomitant administration of acid reducing agents, can result in variable pharmacokinetics and decreased absorption of weakly basic drugs. It is important to identify the… read more here.
Keywords: dissolution; palbociclib; modifiers mitigating; absorption ... See more keywords
Preparation and Evaluation of Ternary Polymeric Blends for Controlled Release Matrices Containing Weakly Basic Model Drug.
Sign Up to like & getrecommendations! Published in 2020 at "Current drug delivery"
DOI: 10.2174/1567201817666200731170040
Abstract: OBJECTIVE The objective of this study was to evaluate the suitability of ternary mixture of smart polymers comprised of Eudragit®E100, Eudragit®L100, and sodium alginate to serve as a carrier for sustained drug release for weakly… read more here.
Keywords: controlled release; release; drug; model drug ... See more keywords
Characterizing the Physicochemical Properties of Two Weakly Basic Drugs and the Precipitates Obtained from Biorelevant Media
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14020330
Abstract: Generally, some weakly basic insoluble drugs will undergo precipitate and redissolution after emptying from the stomach to the small intestinal, resulting in the limited ability to predict the absorption characteristics of compounds in advance. Absorption… read more here.
Keywords: obtained biorelevant; precipitates obtained; biorelevant media; physicochemical properties ... See more keywords
Design and Optimization of a Nanoparticulate Pore Former as a Multifunctional Coating Excipient for pH Transition-Independent Controlled Release of Weakly Basic Drugs for Oral Drug Delivery
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020547
Abstract: Bioavailability of weakly basic drugs may be disrupted by dramatic pH changes or unexpected pH alterations in the gastrointestinal tract. Conventional organic acids or enteric coating polymers cannot address this problem adequately because they leach… read more here.
Keywords: transition; controlled release; release; drug ... See more keywords
Developing a Formulation Strategy Coupled with PBPK Modeling and Simulation for the Weakly Basic Drug Albendazole
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041040
Abstract: Albendazole (ABZ) is a weakly basic drug that undergoes extensive presystemic metabolism after oral administration and converts to its active form albendazole sulfoxide (ABZ_SO). The absorption of albendazole is limited by poor aqueous solubility, and… read more here.
Keywords: formulation; pbpk modeling; basic drug; abz ... See more keywords