In vitro tetraploidization for the augmentation of wedelolactone in Sphagneticola calendulacea (L.) Pruski
Sign Up to like & getrecommendations! Published in 2018 at "Acta Physiologiae Plantarum"
DOI: 10.1007/s11738-018-2786-5
Abstract: A practical and reliable method for in vitro tetraploidization of Sphagneticola calendulacea (L.) Pruski [synonym Wedelia chinensis (Osbeck) Merrill] has been established to enhance the production of wedelolactone. Shoot tip and nodal explants from in… read more here.
Keywords: calendulacea pruski; vitro tetraploidization; wedelolactone; sphagneticola calendulacea ... See more keywords
Wedelolactone, a plant coumarin, prevents vascular smooth muscle cell proliferation and injury-induced neointimal hyperplasia through Akt and AMPK signaling
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2017.06.011
Abstract: Abstract Wedelolactone (WDL) is a natural compound derived from Chinese herbal medicine Eclipta prostrate L, and has been reported to exhibit various effects potentially beneficial for human health. However, the possible preventive effects of WDL… read more here.
Keywords: akt ampk; proliferation; wedelolactone; neointimal hyperplasia ... See more keywords
Exploring the Multitarget Activity of Wedelolactone against Alzheimer’s Disease: Insights from In Silico Study
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c08014
Abstract: In this study, Wedelolactone’s multitarget activity against Alzheimer’s disease was examined using density functional theory and molecular docking techniques. At physiological pH, the pKa and molar fractions have been estimated. The most likely relative rate… read more here.
Keywords: alzheimer disease; multitarget activity; activity; wedelolactone ... See more keywords
Wedelolactone Enhances Odontoblast Differentiation by Promoting Wnt/β-Catenin Signaling Pathway and Suppressing NF-κB Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular reprogramming"
DOI: 10.1089/cell.2018.0004
Abstract: Wedelolactone is a multitarget natural plant compound with many pharmacological activities, including anti-inflammatory, anticancer, and antiosteoporosis. In this study, dental pulp stem cells (DPSCs) were treated with or without wedelolactone. We found that wedelolactone stimulated… read more here.
Keywords: catenin; signaling pathway; wedelolactone; odontoblast differentiation ... See more keywords
Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis
Sign Up to like & getrecommendations! Published in 2020 at "Cell Proliferation"
DOI: 10.1111/cpr.12868
Abstract: Wedelolactone exhibits regulatory effects on some inflammatory diseases. However, the anti‐inflammatory mechanism of wedelolactone has not been entirely unravelled. Therefore, the present study focuses on investigating the mechanism of wedelolactone on NLRP3 inflammasome in macrophages… read more here.
Keywords: thr phosphorylation; facilitates ser; wedelolactone; wedelolactone facilitates ... See more keywords
Wedelolactone, a component from Eclipta prostrata (L.) L., inhibits the proliferation and migration of head and neck squamous cancer cells through the AhR pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201023666220307110554
Abstract: BACKGROUND Ecliptae prostrata (L.) L. has been widely used in east Asia with reported biological activities including anti-cancer properties. OBJECTIVE We aimed to investigate the effect of ethyl acetate extract of Ecliptae prostrata (L.) L.… read more here.
Keywords: proliferation migration; prostrata; migration; wedelolactone ... See more keywords
Wedelolactone Attenuates N-methyl-N-nitrosourea-Induced Retinal Neurodegeneration through Suppression of the AIM2/CASP11 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020311
Abstract: N-methyl-N-nitrosourea (NMU) is widely used to model oxidative stress and inflammation mediated retinal neurodegeneration. Wedelolactone (WD) is known to have antioxidant, anti-inflammatory, and neuroprotective roles. This study tested the therapeutic potential of WD in NMU-induced… read more here.
Keywords: retinal neurodegeneration; induced retinal; neurodegeneration; wedelolactone ... See more keywords
Development and Validation of an Ultra-Performance Liquid Chromatography Method for the Determination of Wedelolactone in Rat Plasma and its Application in a Pharmacokinetic Study
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24040762
Abstract: Wedelolactone is a coumarin ether with significant hepatoprotective effects. However, there are few pharmacokinetic studies of wedelolactone, which will affect the studies of its efficacy and potential toxicity. In this study, a selective ultra-performance liquid… read more here.
Keywords: rat plasma; study; method; wedelolactone rat ... See more keywords