SETD8C302R Mutation Revealed from Myofibroblastoma‐Discordant Monozygotic Twins Leads to p53/p21 Deficit and WEE1 Inhibitor Sensitivity
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Science"
DOI: 10.1002/advs.202001041
Abstract: Abstract High‐throughput gene sequencing has identified various genetic variants as the culprits for some common hereditary cancers. However, the heritability of a substantial proportion of cancers remains unexplained, which may result from rare deleterious mutations… read more here.
Keywords: p53 p21; myofibroblastoma; wee1 inhibitor; setd8c302r mutation ... See more keywords
Abstract B183: The WEE1 inhibitor AZD1775 in combination with chemotherapy in Asian patients with advanced solid tumors: a phase Ib study
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-b183
Abstract: Background: AZD1775 is a first-in-class, potent, selective WEE1 inhibitor that has shown acceptable toxicity, linear PK, target engagement, and antitumor activity in combination with chemotherapy (phase I and II studies, both Leijen S et al.,… read more here.
Keywords: combination; wee1 inhibitor; combination chemotherapy; cohort ... See more keywords
Abstract 2796: Tumor pharmacokinetics, pharmacodynamics and efficacy analysis of WEE1 inhibitor, zn-c3 in patient-derived xenograft models of glioblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2796
Abstract: WEE1 kinase regulates G2/M checkpoint transition via phosphorylation of CDK1 and prevents entry into mitosis. WEE1 inhibition increases genomic instability due to G2/M checkpoint inactivation and can result in mitotic catastrophe as monotherapy or when… read more here.
Keywords: derived xenograft; tumor; wee1 inhibitor; patient derived ... See more keywords
Uterine Serous Carcinoma Responds to the WEE1 Inhibitor Adavosertib.
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DOI: 10.1158/2159-8290.cd-rw2021-043
Abstract: The overall response rate to adavosertib was 29.4%; no biomarkers predicting response were found. read more here.
Keywords: serous carcinoma; carcinoma responds; uterine serous; wee1 inhibitor ... See more keywords
Effects of Wee1 inhibitor adavosertib on patient-derived high-grade serous ovarian cancer cells are multiple and independent of homologous recombination status
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.954430
Abstract: Objective A major challenge in the treatment of platinum-resistant high-grade serous ovarian cancer (HGSOC) is lack of effective therapies. Much of ongoing research on drug candidates relies on HGSOC cell lines that are poorly documented.… read more here.
Keywords: cell; ovarian cancer; hgsoc; cell lines ... See more keywords