Computational fragment-based design of Wee1 kinase inhibitors with tricyclic core scaffolds
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DOI: 10.1007/s11224-018-1176-3
Abstract: Wee1 is cell cycle protein comprising a kinase domain and is a validated cancer target. We have designed molecules with variable tricyclic core scaffolds [6-6-5] system and extended them based on the chemical space available… read more here.
Keywords: core scaffolds; kinase; wee1 kinase; tricyclic core ... See more keywords
Inhibitors of cell cycle checkpoint target Wee1 kinase – a patent review (2003–2022)
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DOI: 10.1080/13543776.2022.2166827
Abstract: ABSTRACT Introduction DNA damage repair in most malignancies with mutation of p53 is more dependent on the G2/M checkpoint. Wee1 kinase is a key regulator of the G2/M checkpoint. If Wee1 is inhibited, it results… read more here.
Keywords: 2003 2022; checkpoint; review; wee1 kinase ... See more keywords
WEE1 kinase inhibitor MK-1775 sensitizes oral tongue squamous cell carcinoma cells to radiation irrespective of TP53 status.
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DOI: 10.1111/odi.14269
Abstract: OBJECTIVE Oral tongue squamous cell carcinoma (OTSCC) frequently harbors non-functional p53 and depends on G2/M checkpoint mediated by WEE1. WEE1 suppression has been identified as a promising anti-tumor strategy. This study investigated the capacity of… read more here.
Keywords: cell; inhibitor; oral tongue; radiation ... See more keywords