Abstract 7121: The novel WEE1i, APR-1051, is a potentially well tolerated and effective treatment for cyclin E-overexpressing cancers
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-7121
Abstract: Previous studies have demonstrated that WEE1 inhibitors (WEE1i) are a promising cancer therapeutic through synthetic lethality with Cyclin E overexpression. One challenge for two of the leading WEE1i, AZD1775 and ZN-c3, has been the observed… read more here.
Keywords: apr; cancer; treatment; wee1i ... See more keywords
Targeting WEE1 Kinase in Gynecological Malignancies
Sign Up to like & getrecommendations! Published in 2024 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s462056
Abstract: Abstract WEE1 kinase is involved in the G2/M cell cycle checkpoint control and DNA damage repair. A functional G2/M checkpoint is crucial for DNA repair in cancer cells with p53 mutations since they lack a… read more here.
Keywords: dna damage; wee1i; gynecological malignancies; wee1 kinase ... See more keywords