Efficacy and Safety of Guselkumab, an Anti–interleukin 23 Monoclonal Antibody, for Palmoplantar Pustulosis: A Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2017.5937
Abstract: Importance Palmoplantar pustulosis (PPP) is a recalcitrant skin disease with no biologics currently approved for treatment. The involvement of interleukin 23 (IL-23) and cytokines of the type 17 helper T cell lineage in the pathogenesis… read more here.
Keywords: week; trial; safety; group ... See more keywords
Efficacy and Safety of Continuous Risankizumab Therapy vs Treatment Withdrawal in Patients With Moderate to Severe Plaque Psoriasis: A Phase 3 Randomized Clinical Trial.
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DOI: 10.1001/jamadermatol.2020.0723
Abstract: Importance Risankizumab selectively inhibits interleukin 23, a cytokine that contributes to psoriatic inflammation. Objective To evaluate the efficacy and safety of risankizumab vs placebo and continuous treatment vs withdrawal in adults with moderate to severe… read more here.
Keywords: week; treatment withdrawal; treatment; patients receiving ... See more keywords
Efficacy and Safety of Upadacitinib vs Dupilumab in Adults With Moderate-to-Severe Atopic Dermatitis: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2021.3023
Abstract: Importance Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disease with an unmet need for treatments that provide rapid and high levels of skin clearance and itch improvement. Objective To assess the safety and… read more here.
Keywords: week; safety; efficacy; upadacitinib dupilumab ... See more keywords
Association of Apremilast With Vascular Inflammation and Cardiometabolic Function in Patients With Psoriasis: The VIP-A Phase 4, Open-label, Nonrandomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2022.3862
Abstract: Importance Psoriasis is an inflammatory condition associated with metabolic and cardiovascular disease. Apremilast, a phosphodiesterase 4 inhibitor, is commonly used for psoriasis and can cause weight loss. Objective To determine the association between apremilast and… read more here.
Keywords: vascular inflammation; nonrandomized clinical; trial; dermatology ... See more keywords
Association Between Rates of Down Syndrome Diagnosis in States With vs Without 20-Week Abortion Bans From 2011 to 2018
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.3684
Abstract: Key Points Question Is there an association between rates of neonatal Down syndrome diagnosis in states that did vs did not enact 20-week abortion bans from 2011 to 2018? Findings In this cohort study of… read more here.
Keywords: 2011 2018; syndrome diagnosis; week; association rates ... See more keywords
Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.0901
Abstract: Importance The effectiveness of currently approved drugs for amyotrophic lateral sclerosis (ALS) is restricted; there is a need to develop further treatments. Initial studies have shown ultrahigh-dose methylcobalamin to be a promising agent. Objective To… read more here.
Keywords: neurology; dose methylcobalamin; trial; week ... See more keywords
Time Course for Benefit and Risk With Ticagrelor and Aspirin in Individuals With Acute Ischemic Stroke or Transient Ischemic Attack Who Carry CYP2C19 Loss-of-Function Alleles: A Secondary Analysis of the CHANCE-2 Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.1457
Abstract: Importance Dual antiplatelet therapy (DAPT) with ticagrelor and aspirin has been found to be effective for secondary prevention after minor ischemic stroke or transient ischemic attack (TIA) in individuals who carry CYP2C19 loss-of-function (LOF) alleles;… read more here.
Keywords: week; ticagrelor aspirin; risk; ischemic stroke ... See more keywords
Association of End Point Definition and Randomized Clinical Trial Duration in Clinical Trials of Schizophrenia Medications.
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DOI: 10.1001/jamapsychiatry.2020.1596
Abstract: Importance Facilitating the development of safe and effective medications for schizophrenia is a public health imperative. Objectives To evaluate the association of shortening randomized clinical trial (RCT) duration with the modification of the Positive and… read more here.
Keywords: clinical trial; week; trial; treatment ... See more keywords
Certolizumab pegol for induction of remission in Crohn's disease
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DOI: 10.1002/14651858.cd012893
Abstract: BACKGROUND Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract, and immune response modulation is the main treatment strategy to induce remission in active CD. Certolizumab pegol (CZP) is a tumor necrosis… read more here.
Keywords: week; response; remission; placebo ... See more keywords
A week in the life of the JACMP
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DOI: 10.1002/acm2.12300
Abstract: Specifically, the week is 27 January–2 February 2018, 3 days before this Editorial is due and 2 days before the Super Bowl. The January issue was published 2 weeks ago and the web activity has… read more here.
Keywords: scholar google; jacmp; week; referral scholar ... See more keywords
Automated tracking of morphologic changes in weekly magnetic resonance imaging during head and neck radiotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of applied clinical medical physics"
DOI: 10.1002/acm2.13959
Abstract: BACKGROUND AND PURPOSE Anatomic changes during head and neck radiotherapy can impact dose delivery, necessitate adaptive replanning, and indicate patient-specific response to treatment. We have developed an automated system to track these changes through longitudinal… read more here.
Keywords: head neck; radiotherapy; neck radiotherapy; week ... See more keywords