Quantitative analysis of Weibel-Palade bodies
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DOI: 10.1371/journal.pone.0278044
Abstract: Weibel Palade bodies (WPBs) are vesicles found in endothelial cells which carry the multimeric protein von Willebrand factor (VWF). As cellular confluency has been shown to influence the number of WPBs in endothelial cells, we… read more here.
Keywords: palade bodies; wpb; weibel palade; wpb nuclei ... See more keywords
Plasma membrane phosphatidylinositol (4,5)-bisphosphate promotes Weibel–Palade body exocytosis
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DOI: 10.26508/lsa.202000788
Abstract: Phosphatidylinositol (4,5)-bisphosphate transiently accumulates at sites of Weibel–Palade body–plasma membrane fusion and promotes agonist-evoked exocytosis of endothelial von-Willebrand factor. Weibel–Palade bodies (WPB) are specialized secretory organelles of endothelial cells that control vascular hemostasis by regulated,… read more here.
Keywords: weibel palade; exocytosis; phosphatidylinositol bisphosphate; plasma membrane ... See more keywords
Sec22b determines Weibel-Palade body length by controlling anterograde endoplasmic reticulum-Golgi transport
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DOI: 10.3324/haematol.2019.242727
Abstract: Von Willebrand factor (VWF) is a multimeric hemostatic protein that is synthesized in endothelial cells, where it is stored for secretion in elongated secretory organelles called Weibel-Palade bodies (WPB). The hemostatic activity of VWF is… read more here.
Keywords: weibel palade; reticulum golgi; vwf; endoplasmic reticulum ... See more keywords
APOLD1 loss causes endothelial dysfunction involving cell junctions, cytoskeletal architecture, and Weibel-Palade bodies, while disrupting hemostasis
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2022.280816
Abstract: Vascular homeostasis is impaired in various diseases thereby contributing to the progression of their underlying pathologies. The endothelial immediate early gene Apolipoprotein L domain-containing 1 (APOLD1) helps to regulate endothelial function. However, its precise role… read more here.
Keywords: palade bodies; cell; weibel palade; apold1 ... See more keywords
HPS6 Regulates the Biogenesis of Weibel–Palade Body in Endothelial Cells Through Trafficking v-ATPase to Its Limiting Membrane
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DOI: 10.3389/fcell.2021.743124
Abstract: The Weibel–Palade body (WPB) is one of the lysosome-related organelles (LROs) in endothelial cells, whose main content is von Willebrand factor (vWF). The biogenesis of LROs is regulated by the Hermansky–Pudlak syndrome (HPS) protein-associated complexes… read more here.
Keywords: membrane; weibel palade; palade body; atpase ... See more keywords
Weibel Palade Bodies: Unique Secretory Organelles of Endothelial Cells that Control Blood Vessel Homeostasis
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DOI: 10.3389/fcell.2021.813995
Abstract: Vascular endothelial cells produce and release compounds regulating vascular tone, blood vessel growth and differentiation, plasma composition, coagulation and fibrinolysis, and also engage in interactions with blood cells thereby controlling hemostasis and acute inflammatory reactions.… read more here.
Keywords: blood vessel; weibel palade; endothelial cells; blood ... See more keywords
Inactivation of Cerebral Cavernous Malformation Genes Results in Accumulation of von Willebrand Factor and Redistribution of Weibel-Palade Bodies in Endothelial Cells
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DOI: 10.3389/fmolb.2021.622547
Abstract: Cerebral cavernous malformations are slow-flow thrombi-containing vessels induced by two-step inactivation of the CCM1, CCM2 or CCM3 gene within endothelial cells. They predispose to intracerebral bleedings and focal neurological deficits. Our understanding of the cellular… read more here.
Keywords: weibel palade; ccm1; endothelial cells; palade bodies ... See more keywords
A Homozygous Deep Intronic Variant Causes Von Willebrand Factor Deficiency and Lack of Endothelial-Specific Secretory Organelles, Weibel–Palade Bodies
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DOI: 10.3390/ijms23063095
Abstract: A type 3 von Willebrand disease (VWD) index patient (IP) remains mutation-negative after completion of the conventional diagnostic analysis, including multiplex ligation-dependent probe amplification and sequencing of the promoter, exons, and flanking intronic regions of… read more here.
Keywords: specific secretory; secretory organelles; weibel palade; von willebrand ... See more keywords
V-ATPase V0a1 promotes Weibel–Palade body biogenesis through the regulation of membrane fission
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DOI: 10.7554/elife.71526
Abstract: Membrane fission, the division of a membrane-bound structure into two discrete compartments, is essential for diverse cellular events, such as endocytosis and vesicle/granule biogenesis; however, the process remains unclear. The hemostatic protein von Willebrand factor… read more here.
Keywords: weibel palade; v0a1; membrane; membrane fission ... See more keywords