An updated weight of evidence approach for deriving a health‐based guidance value for 4‐nonylphenol
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3661
Abstract: 4‐Nonylphenol (NP) is a persistent estrogen‐active compound. Human exposure to NP is primarily through water and food. Although risk assessments of NP have been conducted by the European Union and a few other countries, only… read more here.
Keywords: health based; evidence approach; weight evidence; value ... See more keywords
Quantitative weight of evidence to assess confidence in potential modes of action
Sign Up to like & getrecommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2017.02.017
Abstract: &NA; The evolved World Health Organization/International Programme on Chemical Safety mode of action (MOA) framework provides a structure for evaluating evidence in pathways of causally linked key events (KE) leading to adverse health effects. Although… read more here.
Keywords: confidence; confidence scoring; hypothesized moas; moa ... See more keywords
Hypothesis‐driven weight‐of‐evidence analysis for the endocrine disruption potential of benzene
Sign Up to like & getrecommendations! Published in 2018 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2018.09.027
Abstract: ABSTRACT Exposure to benzene has many sources, from gasoline refueling to tobacco combustion. Although the toxicology of benzene is well studied, the potential for environmental exposure and a heightened interest in identifying substances that may… read more here.
Keywords: methodology; benzene; toxicology; endocrine ... See more keywords
Hypothesis-driven weight of evidence evaluation indicates styrene lacks endocrine disruption potential.
Sign Up to like & getrecommendations! Published in 2023 at "Critical reviews in toxicology"
DOI: 10.1080/10408444.2022.2112652
Abstract: Styrene is among the U.S. EPA's List 2 chemicals for Tier 1 endocrine screening subject to the agency's two-tiered Endocrine Disruptor Screening Program (EDSP). Both U.S. EPA and OECD guidelines require a Weight of Evidence… read more here.
Keywords: evaluation; weight evidence; endocrine disruptor; styrene ... See more keywords
Weight of evidence evaluation for chemical-induced immunotoxicity for PFOA and PFOS: findings from an independent panel of experts
Sign Up to like & getrecommendations! Published in 2023 at "Critical Reviews in Toxicology"
DOI: 10.1080/10408444.2023.2194913
Abstract: Abstract Immunotoxicity is the critical endpoint used by some regulatory agencies to establish toxicity values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). However, the hypothesis that exposure to certain per- and polyfluoroalkyl substances (PFAS)… read more here.
Keywords: panel; pfoa pfos; immunotoxicity; weight evidence ... See more keywords
The burdens of proof: discriminatory power, weight of evidence, and tenacity of belief
Sign Up to like & getrecommendations! Published in 2018 at "Jurisprudence"
DOI: 10.1080/20403313.2018.1439444
Abstract: In The Burdens of Proof 1 Dale A. Nance offers an interpretive theory of civil and criminal fact finding. Being interpretive, the theory’s aim is not to provide a comprehensive and coherent descrip... read more here.
Keywords: burdens proof; proof discriminatory; power weight; discriminatory power ... See more keywords
Thermal Hazards Evaluation Based on Weight of Evidence Method in the Resource Area of Datong River in Qinghai-Tibetan Plateau
Sign Up to like & getrecommendations! Published in 2023 at "Atmosphere"
DOI: 10.3390/atmos14050885
Abstract: With global warming and increasingly frequent human activities in permafrost regions, it is of great significance to accurately and scientifically evaluate the probability and scope of thermal hazards in permafrost regions. Based on remote sensing… read more here.
Keywords: area; ground; weight evidence; evidence method ... See more keywords