A general statistic to test an optimally weighted combination of common and/or rare variants
Sign Up to like & getrecommendations! Published in 2019 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22255
Abstract: Both genome‐wide association study and next‐generation sequencing data analyses are widely employed to identify disease susceptible common and/or rare genetic variants. Rare variants generally have large effects though they are hard to detect due to… read more here.
Keywords: optimally weighted; common rare; rare variants; test ... See more keywords
A Novel Approach Integrating Hierarchical Clustering and Weighted Combination for Association Study of Multiple Phenotypes and a Genetic Variant
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.654804
Abstract: As a pivotal research tool, genome-wide association study has successfully identified numerous genetic variants underlying distinct diseases. However, these identified genetic variants only explain a small proportion of the phenotypic variation for certain diseases, suggesting… read more here.
Keywords: multiple phenotypes; hierarchical clustering; association; association study ... See more keywords